蠕虫及其来源分子干预炎症性疾病的研究进展

doi:10.12140/j.issn.1000-7423.2021.03.014

中国寄生虫学与寄生虫病杂志 ›› 2021, Vol. 39 ›› Issue (3): 380-385.doi: 10.12140/j.issn.1000-7423.2021.03.014

蠕虫及其来源分子干预炎症性疾病的研究进展

陈玉莹¹^,²(), 王晓婷², 戴洋¹^,²^,^*(), 曹俊¹^,²

1 南京医科大学全球健康中心,南京 211166
2 国家卫生健康委员会寄生虫病预防和控制技术重点实验室,江苏省寄生虫与媒介控制技术重点实验室,江苏省血吸虫病防治研究所,无锡 214064

收稿日期:2020-09-14 修回日期:2020-10-28 出版日期:2021-06-30 发布日期:2021-07-05
通讯作者: 戴洋
作者简介:陈玉莹（1996-）,女,硕士研究生,从事寄生虫感染免疫研究。E-mail： 18826108801@163.com
基金资助:
江苏省公益类科研院所自主科研项目(BM2018020);江苏省“科教强卫工程”项目(ZDXKA2016016)

Progress on the intervention of inflammatory conditions by helminthes and their derived molecules

CHEN Yu-ying¹^,²(), WANG Xiao-ting², DAI Yang¹^,²^,^*(), CAO Jun¹^,²

1 Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China
2 National Health Commission Key Laboratory of Parasitic Disease Control and Prevention, Jiangsu Provincial Key Laboratory on Parasite and Vector Control Technology, Jiangsu Institute of Parasitic Diseases, Wuxi 214064, China

Received:2020-09-14 Revised:2020-10-28 Online:2021-06-30 Published:2021-07-05
Contact: DAI Yang
Supported by:
Jiangsu Provincial Department of Science and Technology(BM2018020);Jiangsu Provincial Project of Invigorating Health Care through Science, Technology and Education(ZDXKA2016016)

摘要/Abstract

摘要：

炎症是由机体应对病原体入侵或组织损伤产生的一种复杂的保护性反应,心血管疾病、糖尿病、哮喘、肥胖症等均为炎症相关疾病。近年来,大量证据表明,蠕虫及其来源分子对炎症性疾病具有有效的干预作用,故提出了“蠕虫疗法”这一概念。由于接种活体蠕虫面临较大伦理及安全性方面的争议,目前研究热点聚焦于蠕虫源性抗炎效应分子的筛选、结构解析、抗炎活性的鉴定及验证等方面。本文对蠕虫来源的抗炎活性分子及其干预炎症性疾病作用机制的最新进展进行综述。

关键词: 蠕虫, 抗炎分子, 炎症性疾病, 免疫调控

Abstract:

Inflammation is a complex protective response to pathogen invasion or tissue damage. Inflammation-related diseases include cardiovascular diseases, diabetes, asthma, obesity, etc. In recent years, accumulating evidence has shown that helminthes and their derived molecules can effectively interfere with inflammatory diseases, which leads to the ‘worm therapy’ concept. As administering with live worms is challenged with serious ethical and safety concerns, current research is focusing on the screening and structural analysis of worm-derived anti-inflammatory molecules, and identification and verification of anti-inflammatory effects. This article reviews the latest advances in worm-derived anti-inflammatory active molecules and the mechanisms underlying their intervention of inflammatory diseases.

Key words: Helminth, Anti-inflammatory molecule, Inflammatory diseases, Immune regulation

中图分类号:

R383

陈玉莹, 王晓婷, 戴洋, 曹俊. 蠕虫及其来源分子干预炎症性疾病的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2021, 39(3): 380-385.

CHEN Yu-ying, WANG Xiao-ting, DAI Yang, CAO Jun. Progress on the intervention of inflammatory conditions by helminthes and their derived molecules[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2021, 39(3): 380-385.

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蠕虫及其来源分子干预炎症性疾病的研究进展

Progress on the intervention of inflammatory conditions by helminthes and their derived molecules

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