CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >

2019 , Vol. 37 >Issue 6: 709 - 712

DOI: https://doi.org/10.12140/j.issn.1000-7423.2019.06.017

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Research progress in the role of profilin in parasitic infection and immunity

  • Fei-yu QIN ,
  • Hai-tong SONG ,
  • Xin ZHANG ,
  • Yu-di LI ,
  • Fei YUAN ,
  • Cheng HE ,
  • Zhuan-zhuan LIU
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  • Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogen Biology and Immunology, National Experimental Demonstration Center for Basic Medicine Education, Xuzhou Medical University, Xuzhou 221004, China

Received date: 2019-07-06

  Online published: 2019-12-31

Supported by

Supported by Natural Science Foundation of Jiangsu (No. BK20180994), Natural Science Fund of the Jiangsu Higher Education Institutions (No. 17KJB310017), the Fund for Postdoctoral Research in China (No. 2018M632382), Training Programs of Innovation and Entrepreneurship for College Students in Jiangsu Province (No. 201910313062Y)

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Abstract

Profilin is an actin-binding protein highly conserved in all eukaryotes. It regulates the polymerization and depolymerization of actin, therefore affecting parasite movement and invasion in the host and inducing specific immune responses during parasite infection. Here we reviewed the structure and function of profilin, its role during parasite infection and immune responses in the host and its potential as a vaccine candidate and adjuvant, in order to provide reference for the better prevention and treatment of parasitic diseases.

Key words： Profilin; Parasite; Infection and immunity; Vaccine

Cite this article

Fei-yu QIN , Hai-tong SONG , Xin ZHANG , Yu-di LI , Fei YUAN , Cheng HE , Zhuan-zhuan LIU . Research progress in the role of profilin in parasitic infection and immunity[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2019 , 37(6) : 709 -712 . DOI: 10.12140/j.issn.1000-7423.2019.06.017

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