Objective To evaluate and analysis the schistosomiasis control in model demonstration and expansion areas with infection sources control strategy implemented in Jiangxi Province. Methods The programs of model demonstration and expansion areas for schistosomiasis control were initiated during 2011-2015, where the measures to control infection source of schistosomiasis were implemented. These measures included eliminating farming cattle, replacing the farming cattle with agricultural machine, forbidding grazing on snail-inhabited marshlands, snail control, examination and treatment for resident people and livestock and performing health education. The epidemiological data were collected from these areas from 2010-2018 and analyzed. The infection of resident, livestock and snail in these areas after the implementation of the control measures was compared with that before implementation. The epidemic and control effects were analyzed and evaluated. Results The program covered total 672 villages within 69 townships in 13 counties. In the model demonstration areas, after the implementation of control measures, the infection rate of snail decreased from 0.22% in 2010 to 0 in 2014, and there is no infectious snails found for 4 consecutive years from 2015 to 2018. The positive rate of fecal examination in residents dropped from 1.12% (175/15 585) in 2010 to 0 in 2015, and cattle positive rate dropped from 2.95% (166/5 629) in 2010 to 0 in 2013. In 4 expansion areas, the snail infection rate dropped to 0 after 1 year with the program implemented, with no infectious snails found for 5 consecutive years. The infection rate of cattle dropped to 0 after 1-3 years of the program implementation. Only 7 cases were found with schistosome egg positive in the expansion areas during 2015-2018. Conclusion At the low infection areas, the infection rate of schistosomiasis in people, cattle and snail could be further decreased by implementing the strategy focusing infection source control in the model demonstration area and extension areas. It is necessary to further strengthen the integrated measures for infection source control including banning livestock husbandry in marshlands, as to consolidate control achievements in these demonstration and expansion areas.