CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >

2019 , Vol. 37 >Issue 3: 342 - 345

DOI: https://doi.org/10.12140/j.issn.1000-7423.2019.03.018

INFORMATION REPORTS

Current status of toxoplasmosis misdiagnosis in clinic

  • Hai-ying SU ,
  • Shu-jun YANG ,
  • Hong-juan PENG ,
  • Chun-mei WANG
Expand
  • 1 Second College of Clinical Medicine, Southern Medical University, Guangzhou 510515, China
    2 Department of Special Inspection, No. 421 Hospital of Liberation Army, Guangzhou 510318, China
    3 School of Public Health, Southern Medical University, Guangzhou 510515, China

Received date: 2018-10-10

  Online published: 2019-07-10

Fold

Abstract

To understand the current status of Toxoplasmosis misdiagnosis in clinic, information for the misdiagnosed Toxoplasmosis were collected by searching through PubMed and Tsinghua Tongfang CNKI database from January 2000 to August 2018 and analyzed regarding the type of diseases to which the Toxoplasmosis was misdiagnosed, the location of the infection and lesion, the method of definitive diagnosis, co-infection with HIV and organ transplantation. The possible causes for the misdiagnosis were further discussed. Total 70 related literatures were obtained and a total of 251 misdiagnosed cases were collected. The analytic results showed that Toxoplasmosis was misdiagnosed to 61 different types of diseases. The top two misdiagnosed diseases were iridocyclitis (11.6%, 29/251) and retinitis (8.8%, 22/251) in eyes. The most common locations of the infection and lesion were in brain (33.5%, 84/251), eye (25.5%, 64/251) and liver (12.4%, 31/251). 132 cases were positive for Toxoplasma antibody by serological test; 68 cases (including 25 death cases) were observed with Toxoplasma gondii trophozoites or cysts in tissues by histopathological examination; 13 cases were diagnosed by identification of T. gondii in blood, body fluid and puncture fluid under microscope. Out of the total 251 misdiagnosed Toxoplasmosis, 49 had co-infection with HIV with symptoms of AIDS, 13 had received bone marrow transplantation and 2 received kidney transplantation.

Key words： Toxoplasmosis; Clinical misdiagnosis; Detection

Cite this article

Hai-ying SU , Shu-jun YANG , Hong-juan PENG , Chun-mei WANG . Current status of toxoplasmosis misdiagnosis in clinic[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2019 , 37(3) : 342 -345 . DOI: 10.12140/j.issn.1000-7423.2019.03.018

References

[1] 刘敏, 陈晓光. 中国人群弓形虫病的流行特征分析[J]. 寄生虫与医学昆虫学报, 2010, 17(3): 184-191.
[2] Jones JL, Kruszon-Moran D, Elder S, et al. Toxoplasma gondii infection in the United States, 2011-2014[J]. Am J Trop Med Hyg. 2017, 98(2): 551-557.
[3] Hendrik Wilking, Michael Thamm, Klaus Stark, et al. Prevalence, incidence estimations, and risk factors of Toxoplasma gondii infection in Germany[J]. Sci Rep, 2016, 6: 22551.
[4] 沈继龙. 弓形虫病的若干术语释义及实验室诊断的解读与处置策略[J]. 中国寄生虫学与寄生虫病杂志, 2017, 35(4): 382-386.
[5] 欧阳颗. 弓形虫脑炎研究近况[J]. 临床内科杂志, 2001, 18(4): 255-256.
[6] 蒲德红, 郝卫刚, 陈思源. AIDS合并弓形虫脑病28例误诊分析[J]. 中国实用神经疾病杂志, 2013, 16(19): 73-74.
[7] 梁津. 弓形虫血清学标志物IgG、IgM对艾滋病患者诊断弓形虫脑病的意义[J]. 中国医药指南, 2015, 13(3): 98-99.
[8] 汪文胜, 郭耀平, 宋亭, 等. 弓形体脑病的MRI表现[J]. 实用放射学杂志, 2005, 21(6): 582-584.
[8] [ 9 ] 张明珩, 诸葛传德. 弓形虫病性视网膜脉络膜炎四例9 ] 张明珩, 诸葛传德. 弓形虫病性视网膜脉络膜炎四例[J]. 中华眼科杂志, 1992, 28(2): 114-115.
[10] 郭俊杰. 对178例弓形虫感染临床误诊的探讨[J]. 齐齐哈尔医学院学报, 2005, 26(9): 1037-1038.
[11] Lee MW, Fong KS, Hsu LY, et al. Optic nerve toxoplasmosis and orbital inflammation as initial presentation of AIDS[J]. Graefes Arch Clin Exp Ophthalmol, 2006, 24(11): 1542-1544.
[12] Raus P, Stalmans P, Demeuter E, et al. Unusual retinal vasculitis in a patient with protein S deficiency and systemic toxoplasmosis: a case report[J]. Bull Soc Belge Ophtalmol, 2001(279): 7-12.
[13] 毛青, 杨亚英, 包颜明, 等. 肝脏弓形虫感染的CT表现[J]. 中华放射学杂志, 2005, 39(12): 1331-1332.
[14] 卢慎. 弓形虫性淋巴结炎15例报告[J]. 中国血吸虫病防治杂志, 1992, 4(3): 172-173.
[15] 卢慎. 应用3种方法诊断弓形虫淋巴结炎[J]. 世界感染杂志, 2008, 8(5): 375-378.
[16] 常占平, 王洪芬. 弓形虫病误诊为急性上呼吸道感染1例分析[J]. 中国误诊学杂志, 2009, 9(15): 3540.
[17] Nakazaki S, Saeki N, Itoh S, et al. Toxoplasmic encephalitis in patients with acquired immunodeficiency syndrome: four case reports[J]. Neurol Med Chir (Tokyo), 2000, 40(2): 120-123.
[18] Robert-Gangneux F, Meroni V, Dupont D, et al. Toxoplasmosis in transplant recipients, Europe, 2010-2014[J]. Emerging Infect Dis, 2018, 24(8): 1497-1504.
[19] 严晓岚, 闻礼永, 官亚宜, 等. 《弓形虫病的诊断》标准解读[J]. 中国寄生虫学与寄生虫病杂志, 2016, 34(4): 387-388.
[20] 李桂萍, 崔蓉, 张瑜. 后天获得性弓形虫病11例误诊原因分析[J]. 临床误诊误治, 2009, 22(3): 37.
[21] 陈兴智, 孙新, 夏惠, 等. 弓形虫病三种病原学检查方法的比较[J]. 蚌埠医学院学报, 2004, 29(2): 106-108.
[22] Commodaro AG, Belfort RN, Rizzo LV, et al. Ocular toxoplasmosis: an update and review of the literature[J]. Mem Inst Oswaldo Cruz, 2009, 104(2): 345-350.
[23] 申丽洁, 李伟, 和艳红. 弓形虫病的分子诊断[J]. 中国血吸虫病防治杂志, 2011, 23(4): 465-467.
Options
Outlines

/

〈 〉