CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >

2026 , Vol. 44 >Issue 2: 290 - 295

DOI: https://doi.org/10.12140/j.issn.1000-7423.2026.02.021

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Nanoparticles and their application in vaccine research for important parasitic diseases

  • WU Keke ,
  • WANG Liqun ,
  • LUO Xuenong
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  • 1 Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences; State Key Laboratory for Animal Disease Control and Prevention/Gansu Provincial Key Laboratory of Animal Parasitic Diseases, Lanzhou 730046, Gansu, China
    2 Jiangsu Provincial Collaborative Innovation Center for the Prevention and Control of Major Animal Diseases and Zoonotic Diseases, Yangzhou University, Yangzhou 225009, Jiangsu, China

Received date: 2025-06-11

  Revised date: 2025-11-13

  Online published: 2026-04-24

Supported by

National Key Research and Development Program of China(2023YFD1802401)

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Abstract

Parasitic diseases remain a major global public health concern. Conventional chemotherapy frequently faces limitations, including significant adverse effects and the inability to prevent reinfection. Although prophylactic vaccination represents an ideal strategy for achieving long-term control of parasitic diseases, the development of traditional vaccines has been severely impeded by the complex life cycles, high antigenic variability, and sophisticated immune evasion mechanisms of parasites. In recent years, nanoparticles-leveraging their unique physicochemical properties to integrate antigen protection, targeted delivery, and synergistic immune activation-have provided a new opportunity to overcome the bottlenecks in parasitic vaccine development. In light of this, this article systematically reviews the physicochemical characteristics of various nanoparticles and their latest advances in vaccine research against major parasitic diseases, such as schistosomiasis, toxoplasmosis, and echinococcosis. It provides an in-depth discussion on their mechanisms of action and core advantages in optimizing antigen delivery and immunomodulation. Furthermore, it objectively analyzes the current challenges and future trends facing nanovaccines in clinical translation and industrial application, aiming to provide theoretical insights for the rational design and development strategies of novel parasitic vaccines.

Key words： Parasitic disease; Nanoparticles; Antigen delivery

Cite this article

WU Keke , WANG Liqun , LUO Xuenong . Nanoparticles and their application in vaccine research for important parasitic diseases[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2026 , 44(2) : 290 -295 . DOI: 10.12140/j.issn.1000-7423.2026.02.021

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