CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >

2026 , Vol. 44 >Issue 1: 130 - 136

DOI: https://doi.org/10.12140/j.issn.1000-7423.2026.01.019

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Progress of researches on biological therapies targeting type 2 inflammation and risk of parasitic infections

  • CAI Wenlin ,
  • LIU Xu ,
  • HU Ke
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  • Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, China

Received date: 2025-10-21

  Revised date: 2026-01-14

  Online published: 2026-02-24

Supported by

Interdisciplinary Innovative Talents Foundation from Renmin Hospital of Wuhan University(JCRCYG-2022-012)

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Abstract

Recently, biologics targeting type 2 inflammatory pathways, such as interleukin-4 (IL-4)/IL-13, IL-5, and immunoglobulin E (IgE), have become effective approaches for treatment of type 2 inflammatory diseases. Nevertheless, these biologics not only precisely suppress excessive inflammatory responses, but also interfere with the body’s capability to fight against parasitic infections, thereby increasing the risk of infection. Although such adverse events are relatively rare, their potential associations have been paid attention in clinical practices. Currently, there is still a lack of systematic understanding regarding the exact mechanisms underlying parasitic infections induced by biologics with diverse targets, the characteristics of high-risk populations, and clinical management strategies. This article aims to provide a review of these aspects, so as to provide insights into clinical practices.

Key words： Parasitic infection; Antibody; Monoclonal; Immune response; Biological product

Cite this article

CAI Wenlin , LIU Xu , HU Ke . Progress of researches on biological therapies targeting type 2 inflammation and risk of parasitic infections[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2026 , 44(1) : 130 -136 . DOI: 10.12140/j.issn.1000-7423.2026.01.019

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