CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >
Progress of researches on interactions between sandfly gut microecology and Leishmania infection
Received date: 2025-05-09
Revised date: 2025-07-24
Online published: 2025-10-23
Supported by
National Key Research and Development Program of China(2023YFA1801000);National Key Research and Development Program of China(2023YFA1801001)
Sandflies, as vectors of multiples pathogens, are of significant epidemiological importance, and has been given attention due to their role in transmitting Leishmania. The growth and development of Leishmania is affected by the diverse microbial communities present in the sandfly gut, which also induces differential gene expression in the sandfly gut. This article summarizes the composition of the sandfly gut microbiota and their interactions with Leishmania, and alterations of functional characteristics in the sandfly gut caused by the parasite. Sandflies, Leishmania, gut microbiota, and gene expression form a complex network, and deciphering their interactions may provide more strategies for leishmaniasis management and sandfly vector control.
Key words： Sandfly; Leishmania; Gut microbiota; Gut function
HE Yaqi , CUI Lei , FANG Yuan , ZHOU Zhengbin , ZHANG Yi . Progress of researches on interactions between sandfly gut microecology and Leishmania infection[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2025 , 43(5) : 711 -717 . DOI: 10.12140/j.issn.1000-7423.2025.05.017
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