CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >

2025 , Vol. 43 >Issue 5: 705 - 710

DOI: https://doi.org/10.12140/j.issn.1000-7423.2025.05.016

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Progress of researches on the role of IL-10 in the immunosuppressive microenvironment of alveolar echinococcosis

  • WANG Shujun ,
  • HAN Fei ,
  • ZHANG Huixia ,
  • ZHONG Shigui ,
  • ZHAO Yumin
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  • 1 School of Basic Medical Sciences, Gansu Medical College, Pingliang 744000, Gansu, China
    2 School of Public Health, Guilin Medical University, Guilin 541000, Guangxi, China

Received date: 2025-04-30

  Revised date: 2025-07-17

  Online published: 2025-10-13

Supported by

Gansu Provincial Higher Education Industry Support Program(2022CYZC-72);Kongtong District Key Research and Development Project of Science and Technology Program in Pingliang City(PL-KT-204-2-006);Gansu Provincial Key Talent Program

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Abstract

Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by infection with Echinococcus multilocularis larvae in hosts. As an exogenous substance, persistent larval E. multilocularis infections lead to suppression of cellular immune functions and dysregulation of cytokine secretion in hosts, thereby creating a unique immunosuppressive microenvironment in hosts. As a key anti-inflammatory cytokine, interleukin-10 (IL-10) plays a pivotal role in the immunomodulation of echinococcosis. This review presents the formation of the immunosuppressive microenvironment of AE, analyzes the biological characteristics of IL-10, its regulatory effects on immune cell functions, and its interplay with other cytokines, and discusses the mechanisms of the contribution of IL-10 to shaping the immunosuppressive microenvironment of AE, so as to provide new theoretical evidence for AE treatment and potential therapeutic targets of AE.

Key words： Alveolar echinococcosis; Immunosuppression; Immune microenvironment; Interleukin 10

Cite this article

WANG Shujun , HAN Fei , ZHANG Huixia , ZHONG Shigui , ZHAO Yumin . Progress of researches on the role of IL-10 in the immunosuppressive microenvironment of alveolar echinococcosis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2025 , 43(5) : 705 -710 . DOI: 10.12140/j.issn.1000-7423.2025.05.016

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