CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >

2025 , Vol. 43 >Issue 3: 423 - 428

DOI: https://doi.org/10.12140/j.issn.1000-7423.2025.03.018

Original article

Progress of researches on the structure and biological functions of protein disulfide isomerase in apicomplexan protozoa

  • WANG Luyang ,
  • ZHANG Qian ,
  • ZHANG Sumei ,
  • ZHANG Longxian
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  • College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, Henan, China

Received date: 2024-12-25

  Revised date: 2025-02-10

  Online published: 2025-05-27

Supported by

National Natural Science Foundation of China(32172882)

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Abstract

Apicomplexan protozoa are a class of obligate intracellular parasites, and most of them are pathogens of zoonoses, with a wide range of hosts, causing huge economic losses to the livestock breeding industry and posing great threats to public health security. It has been demonstrated that protein disulfide isomerase (PDI) is widely present in apicomplexan protozoa, which is mainly associated with the invasion, adhesion and cellular immunity of parasites and plays an important role in the growth and development process of parasites. This review summarizes the advances in the structure and biological functions of PDI in apicomplexan protozoa, so as to provide insights into management of parasitic diseases and research and development of vaccines against parasitic diseases.

Key words： Apicomplexan protozoa; Protein disulfide isomerase; Enzyme structure; Biological function

Cite this article

WANG Luyang , ZHANG Qian , ZHANG Sumei , ZHANG Longxian . Progress of researches on the structure and biological functions of protein disulfide isomerase in apicomplexan protozoa[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2025 , 43(3) : 423 -428 . DOI: 10.12140/j.issn.1000-7423.2025.03.018

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