CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >

2025 , Vol. 43 >Issue 3: 416 - 422

DOI: https://doi.org/10.12140/j.issn.1000-7423.2025.03.017

Original article

Research progress on calreticulin in parasitic helminths and its role in immunity

  • ZHAO Yuyuan ,
  • WANG Sirui ,
  • WANG Mengqi ,
  • DUAN Rui ,
  • HE Peixia ,
  • SUN Shumin
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  • 1 College of Animal Science and Technology, Inner Mongolia Minzu University, Tongliao 028000, Inner Mongolia, China
    2 College of Veterinary Medicine, Yunnan Agricultural University, Kunming 650201, Yunnan, China

Received date: 2024-09-13

  Revised date: 2024-11-27

  Online published: 2025-06-18

Supported by

National Natural Science Foundation of China(31960707);National Natural Science Foundation of China(32160842);National Natural Science Foundation of China(32460893);Inner Mongolia Autonomous Region Science and Technology Program(2022YFDZ0049);Basic scientific research funds for universities directly under the Inner Mongolia Autonomous Region(GXKY22042);Yunnan Province Special Project for Building a Science and Technology Innovation Center for South and Southeast Asia-Yunnan Province International Joint Research and Development Center for Veterinary Pharmaceuticals(202403AP140012)

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Abstract

Calreticulin is a soluble Ca2+-binding protein that is mainly present endoplasmic reticulum, which has a variety of biological functions, such as Ca2+ signal transduction, protein folding, and antigen presentation. The calreticulin of parasitic helminths is secreted by the worm body or expressed on the surface of the worm body, which plays an important role in the parasite motility, growth and development. In addition, the calreticulin of some helminths is strongly associated with its immune evasion process. This review summarizes the structure composition and function of calreticulin, and discusses the mechanisms underlying the regulation of host Th1/Th2 immune responses and the regulatory mechanisms of host immune cells, immune molecules and complement system by calreticulin, so as to provide new insights into management of helminthiasis.

Key words： Parasitic helminth; Calreticulin; Immune response; Immune evasion

Cite this article

ZHAO Yuyuan , WANG Sirui , WANG Mengqi , DUAN Rui , HE Peixia , SUN Shumin . Research progress on calreticulin in parasitic helminths and its role in immunity[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2025 , 43(3) : 416 -422 . DOI: 10.12140/j.issn.1000-7423.2025.03.017

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