CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >
Research progress of macrophage regulation of liver fibrosis induced by alveolar echinococcosis
Received date: 2024-05-28
Revised date: 2024-09-26
Online published: 2025-01-14
Supported by
National Natural Science Foundation of China(82460403);Industrial Support Program Project for Colleges and Universities in Gansu Province(2022CYZC-72)
Alveolar echinococcosis (AE) is a zoonotic parasitic disease that poses a serious threat to human health and the development of animal husbandry. The augmented infiltration of various immune cells (including macrophages) around AE lesions can lead to fibrosis in various important organs, primarily the liver, and might progress into cirrhosis, liver cancer, and other serious disorders. Several types of macrophages manifest as M1 or M2 macrophages at different stages of AE liver inflammation and fibrosis formation, secreting pro-inflammatory and anti-inflammatory cytokines to promote the clearance of echinococcus in the early stage and exerting an anti-inflammatory effect in the middle and late stages, thereby playing a regulatory role in AE liver fibrosis formation. In this article, the regulatory mechanisms of several types of macrophages in AE-induced liver fibrosis are discussed.
Key words： Alveolar Echinococcosis; Macrophage; Liver Fibrosis
YIN Xianmin , CHONG Shigui , CHEN Gen , QIN Junmei , ZHAO Yumin . Research progress of macrophage regulation of liver fibrosis induced by alveolar echinococcosis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2024 , 42(6) : 790 -795 . DOI: 10.12140/j.issn.1000-7423.2024.06.015
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