CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >
Research advances on host cell-autonomous immunity against Toxoplasma gondii
Received date: 2024-05-21
Revised date: 2024-07-25
Online published: 2024-10-22
Supported by
Zhejiang Provincial Health High-level Talent Project-New Talent in Medical Field(2020-35);Zhejiang Province Key Research and Development Projects(2022C031109)
Toxoplasma gondii is one of the most common infectious agents in humans and animals, causing zoonotic toxoplasmosis, which poses a serious hazard to human health and animal husbandry production. Cell-autonomous immunity is an intrinsic immune response that occurs within individual cells to limit the replication and spread of pathogens (e.g., bacteria, viruses, parasites, etc.) that invade the cells. After infection of host cells by T. gondii, cell-autonomous immunity is mainly regulated by interferon-induced indoleamine 2,3-dioxygenase (IDO), inducible nitric oxide synthase (iNOS), GTPase family enzymes, autophagy-related proteins, and ubiquitylation products, all of which play an important role in host cell resistance to T. gondii. In this paper, we reviewed the research advances on the autonomous immune response of host cell against T. gondii, aiming to provide new directions for the prevention and treatment of toxoplasmosis.
Key words： Toxoplasma gondii; Cell-autonomous immunity; Interferon-γ
LI Shiyu , LI Jing , LU Shaohong , ZHENG Bin . Research advances on host cell-autonomous immunity against Toxoplasma gondii[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2024 , 42(5) : 653 -658 . DOI: 10.12140/j.issn.1000-7423.2024.05.014
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