CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >
Research on the progress of programmed cell death in echinococcosis
Received date: 2023-12-07
Revised date: 2024-01-28
Online published: 2024-04-25
Supported by
Province Natural Science Foundation of Qinghai(2023-ZJ-992Q)
Echinococcosis is a serious zoonosis disease caused by the metacestode stage larval of Echinococcus granulosus and E. mulculoris. Humans as an intermediate host infected by the larvae stages of the parasites through accidental ingestion of the eggs. Programmed cell death is common in the growth and development of Echinococcus. Programmed cell death includes apoptosis, pyroptpsis, autophagy and ferroptosis. In this review, we summarized the role of programmed cell death pathways in the echinococcosis and try to provide a basic theoryto explore potential targets for the prevention and treatment of echinococcosis.
DAWA Zhuoma , LIU Chuanchuan , FAN Haining . Research on the progress of programmed cell death in echinococcosis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2024 , 42(2) : 259 -266 . DOI: 10.12140/j.issn.1000-7423.2024.02.018
| [1] | Stojkovic M, Junghanss T. Cystic and alveolar echinococcosis[J]. Handb Clin Neurol, 2013, 114: 327-334. |
| [2] | Wen H, Vuitton L, Tuxun T, et al. Echinococcosis: advances in the 21st century[J]. Clin Microbiol Rev, 2019, 32(2): e00075-18. |
| [3] | Lymbery AJ. Phylogenetic pattern, evolutionary processes and species delimitation in the Genus Echinococcus[J]. Adv Parasitol, 2017, 95: 111-145. |
| [4] | Lin XY, Ouyang SY, Zhi CX, et al. Focus on ferroptosis, pyroptosis, apoptosis and autophagy of vascular endothelial cells to the strategic targets for the treatment of atherosclerosis[J]. Arch Biochem Biophys, 2022, 715: 109098. |
| [5] | Obeng E. Apoptosis (programmed cell death) and its signals: a review[J]. Rev Brasleira De Biol, 2021, 81(4): 1133-1143. |
| [6] | N?ssing C, Ryan KM. 50 years on and still very much alive: ‘Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics’[J]. Br J Cancer. 2023, 128(3): 426-431. |
| [7] | Bedoui S, Herold MJ, Strasser A. Emerging connectivity of programmed cell death pathways and its physiological implications[J]. Nat Rev Mol Cell Biol, 2020, 21(11): 678-695. |
| [8] | Spotin A, Majdi MMA, Sankian M, et al. The study of apoptotic bifunctional effects in relationship between host and parasite in cystic echinococcosis: a new approach to suppression and survival of hydatid cyst[J]. Parasitol Res, 2012, 110(5): 1979-1984. |
| [9] | Mamuti W, Sako Y, Nakao M, et al. Recent advances in characterization of Echinococcus antigen B[J]. Parasitol Int, 2006, 55 Suppl: S57-S62. |
| [10] | Paredes R, Jiménez V, Cabrera G, et al. Apoptosis as a possible mechanism of infertility in Echinococcus granulosus hydatid cysts[J]. J Cell Biochem, 2007, 100(5): 1200-1209. |
| [11] | Cheng Z, Zhu S, Wang L, et al. Identification and characterisation of Emp53, the homologue of human tumor suppressor p53, from Echinococcus multilocularis: its role in apoptosis and the oxidative stress response[J]. Int J Parasitol, 2015, 45(8): 517-526. |
| [12] | Wang N, Zhan JF, Guo C, et al. Molecular characterisation and functions of Fis1 and PDCD6 genes from Echinococcus granulosus[J]. Int J Mol Sci, 2018, 19(9): 2669. |
| [13] | Giri BR, Roy B. Cysticercus fasciolaris infection induced oxidative stress and apoptosis in rat liver: a strategy for host-parasite cross talk[J]. Parasitol Res, 2016, 115(7): 2617-2624. |
| [14] | Zhan JF, Song HY, Wang N, et al. Molecular and functional characterization of inhibitor of apoptosis proteins (IAP, BIRP) in Echinococcus granulosus[J]. Front Microbiol, 2020, 11: 729. |
| [15] | Mokhtari AM, Sankian M, Eftekharzadeh MI, et al. Apoptosis of human lymphocytes after exposure to hydatid fluid[J]. Iran J Parasitol, 2011, 6(2): 9-16. |
| [16] | Nono JK, Pletinckx K, Lutz MB, et al. Excretory/secretory-products of Echinococcus multilocularis larvae induce apoptosis and tolerogenic properties in dendritic cells in vitro[J]. PLoS Negl Trop Dis, 2012, 6(2): e1516. |
| [17] | Li JJ, Tang GY, Qin WJ, et al. Toxic effects of arsenic trioxide on Echinococcus granulosus protoscoleces through ROS production, and Ca2+-ER stress-dependent apoptosis[J]. Acta Biochim Biophys Sin, 2018, 50(6): 579-585. |
| [18] | Ahmadpour E, Spotin A, Moghimi A, et al. Tumor suppressor p73 induces apoptosis of murine peritoneal cell after exposure to hydatid cyst antigens; a possibly survival mechanism of cystic echinococcosis in vivo mice model[J]. PLoS One, 2023, 18(10): e0292434. |
| [19] | Xu K, Yin FJ, Zhang YG, et al. Effect of polylocular Echinococcus multilocularis cyst fluid on apoptosis and autophagy of mouse hepatocytes[J]. Acad J Chin PLA Med Sch, 2022, 43(1): 81-86, 94. (in Chinese) |
| (徐凯, 尹凤娇, 张耀刚, 等. 多房棘球蚴囊液对小鼠肝细胞凋亡与自噬影响的研究[J]. 解放军医学院学报, 2022, 43(1): 81-86, 94.) | |
| [20] | Hu HH, Kang JF, Chen R, et al. Drug-induced apoptosis of Echinococcus granulosus protoscoleces[J]. Parasitol Res, 2011, 109(2): 453-459. |
| [21] | Naseri M, Akbarzadeh A, Spotin A, et al. Scolicidal and apoptotic activities of albendazole sulfoxide and albendazole sulfoxide-loaded PLGA-PEG as a novel nanopolymeric particle against Echinococcus granulosus protoscoleces[J]. Parasitol Res, 2016, 115(12): 4595-4603. |
| [22] | Shahnazi M, Azadmehr A, Jondabeh MD, et al. Evaluating the effect of Myrtus communis on programmed cell death in hydatid cyst protoscolices[J]. Asian Pac J Trop Med, 2017, 10(11): 1072-1076. |
| [23] | Moghadaszadeh M, Khayyati M, Spotin A, et al. Scolicidal and apoptotic activities of 5-hydroxy-1,4-naphthoquinone as a potent agent against Echinococcus granulosus protoscoleces[J]. Pharmaceuticals, 2021, 14(7): 623. |
| [24] | Ma RJ, Qin WJ, Xie YM, et al. Dihydroartemisinin induces ER stress-dependent apoptosis of Echinococcus protoscoleces in vitro[J]. Acta Biochim Biophys Sin, 2020, 52(10): 1140-1147. |
| [25] | Dikic I, Elazar Z. Mechanism and medical implications of mammalian autophagy[J]. Nat Rev Mol Cell Biol, 2018, 19(6): 349-364. |
| [26] | Brier LW, Ge L, Stjepanovic G, et al. Regulation of LC3 lipidation by the autophagy-specific class Ⅲ phosphatidylinositol-3 kinase complex[J]. Mol Biol Cell, 2019, 30(9): 1098-1107. |
| [27] | Yang ZF, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation[J]. Curr Opin Cell Biol, 2010, 22(2): 124-131. |
| [28] | Wang NB, Zhang QX, Luo LY, et al. β-asarone inhibited cell growth and promoted autophagy via P53/Bcl-2/Bclin-1 and P53/AMPK/mTOR pathways in Human Glioma U251 cells[J]. J Cell Physiol, 2018, 233(3): 2434-2443. |
| [29] | Fan SJ, Yue LY, Wan W, et al. Inhibition of autophagy by a small molecule through covalent modification of the LC3 protein[J]. Angew Chem Int Ed Engl, 2021, 60(50): 26105-26114. |
| [30] | Parola M, Pinzani M. Liver fibrosis: pathophysiology, pathogenetic targets and clinical issues[J]. Mol Aspects Med, 2019(65): 37-55. |
| [31] | Hernández-Gea V, Ghiassi-Nejad Z, Rozenfeld R, et al. Autophagy releases lipid that promotes fibrogenesis by activated hepatic stellate cells in mice and in human tissues[J]. Gastroenterology, 2012, 142(4): 938-946. |
| [32] | Shmarakov IO, Jiang HG, Liu J, et al. Hepatic stellate cell activation: a source for bioactive lipids[J]. Biochim Biophys Acta Mol Cell Biol Lipids, 2019, 1864(5): 629-642. |
| [33] | Wang BY, Yang H, Fan YY, et al. 3-methyladenine ameliorates liver fibrosis through autophagy regulated by the NF-κB signaling pathways on hepatic stellate cell[J]. Oncotarget, 2017, 8(64): 107603-107611. |
| [34] | Gao JH, Wei B, de Assuncao TM, et al. Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis[J]. J Hepatol, 2020, 73(5): 1144-1154. |
| [35] | Wei XL, Xu Q, Rexiti FL, et al. Dynamic changes of DC and T cell subsets in mice during Echinococcus multilocularis infection[J]. Cent Eur J Immunol, 2014, 39(1): 19-24. |
| [36] | Ma XJ, Shang M, Yin QC, et al. Maturation of dendritic cells in peripheral blood of patients with alveolar echinococcosis[J]. China Trop Med, 2019, 19(2): 111-115. (in Chinese) |
| (马晓静, 尚梅, 尹启超, 等. 泡型肝包虫患者外周血树突状细胞成熟度[J]. 中国热带医学, 2019, 19(2): 111-115.) | |
| [37] | Gao XY, Zhang GH, Huang L. Modulation of human melanoma cell proliferation and apoptosis by hydatid cyst fluid of Echinococcus granulosus[J]. Onco Targets Ther, 2018, 11: 1447-1456. |
| [38] | Deng J, Huang DL, Zhang YG. Effect of Echinococcus multilocularis infections on mitochondrial functions of macrophages[J]. Chin J Schisto Control, 2021, 33(5): 470-475. (in Chinese) |
| (邓珺, 黄登亮, 张耀刚, 等. 多房棘球蚴感染对巨噬细胞线粒体功能的影响[J]. 中国血吸虫病防治杂志, 2021, 33(5): 470-475.) | |
| [39] | Jin GQ, Zhang ZH, Feng HJ, et al. Beneficial effect of Pink1/Parkin pathway-mediated mitophagy on preventing cellular damage brought on by Echinococcus multilocularis in AML12 cells[J]. Asian J Surg, 2024, 47(1): 571-573. |
| [40] | Lodder J, Dena?s T, Chobert MN, et al. Macrophage autophagy protects against liver fibrosis in mice[J]. Autophagy, 2015, 11(8): 1280-1292. |
| [41] | Loos JA, Caparros PA, Nicolao MC, et al. Identification and pharmacological induction of autophagy in the larval stages of Echinococcus granulosus: an active catabolic process in calcareous corpuscles[J]. Int J Parasitol, 2014, 44(7): 415-427. |
| [42] | Nicolao MC, Loos JA, Rodrigues RC, et al. Bortezomib initiates endoplasmic reticulum stress, elicits autophagy and death in Echinococcus granulosus larval stage[J]. PLoS One, 2017, 12(8): e0181528. |
| [43] | Loos JA, Nicolao MC, Cumino AC. Metformin promotes autophagy in Echinococcus granulosus larval stage[J]. Mol Biochem Parasitol, 2018, 224: 61-70. |
| [44] | Loos JA, Dávila VA, Rodrígues CR, et al. Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis[J]. PLoS Negl Trop Dis, 2017, 11(2): e0005370. |
| [45] | Loos JA, Negro P, Cumino AC. In vitro anti-echinococcal activity of octreotide: additive effect of metformin linked to autophagy[J]. Acta Trop, 2020, 203: 105312. |
| [46] | Shi JJ, Gao WQ, Shao F. Pyroptosis: gasdermin-mediated programmed necrotic cell death[J]. Trends Biochem Sci, 2017, 42(4): 245-254. |
| [47] | Shi JJ, Zhao Y, Wang YP, et al. Inflammatory caspases are innate immune receptors for intracellular LPS[J]. Nature, 2014, 514(7521): 187-192. |
| [48] | Casaravilla C, Pittini á, Rückerl D, et al. Activation of the NLRP3 inflammasome by particles from the Echinococcus granulosus laminated layer[J]. Infect Immun, 2020, 88(9): e00190-e00120. |
| [49] | Chen CS, Zhang YG, Wang HJ, et al. Effect and mechanism of reactive oxygen species-mediated NOD-like receptor family pyrin domain-containing 3 inflammasome activation in hepatic alveolar echinococcosis[J]. World J Gastroenterol, 2023, 29(14): 2153-2171. |
| [50] | Wang T. Expression and significance of GSDMD/Caspase-1, Caspase-4 and Caspase-5 in hepatic alveolar echinococcosis[D]. Xining: Qinghai University, 2019: 8-13. (in Chinese) |
| (王涛. GSDMD/Caspase-1、Caspase-4、Caspase-5等焦亡相关因子在肝泡型包虫病的表达及其意义[D]. 西宁: 青海大学, 2019: 8-13). | |
| [51] | Nie R, Li WD, Ye GB, et al. Research progress on the role of pyroptosis inhuman parasitic diseases[J]. Chin J Parasitol Parasit Dis, 2022, 40(6): 780-785, 791. (in Chinese) |
| (乜茹, 李文登, 冶赓博, 等. 细胞焦亡在人体寄生虫病中的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2022, 40(6): 780-785, 791.) | |
| [52] | Liu J, Kang R, Tang DL. Signaling pathways and defense mechanisms of ferroptosis[J]. FEBS J, 2022, 289(22): 7038-7050. |
| [53] | Tang DL, Chen X, Kang R, et al. Ferroptosis: molecular mechanisms and health implications[J]. Cell Res, 2021, 31(2): 107-125. |
| [54] | Aslam H, Bi S, Irshadullah M. Analysis of antioxidant enzymes and oxidative stress markers in the liver of naturally infected Indian water buffalo (Bubalus bubalis) with cystic echinococcosis[J]. J Parasit Dis, 2023, 47(2): 340-348. |
| [55] | Heidarpour M, Mohri M, Borji H, et al. Oxidant/antioxidant status in cattle with liver cystic echinococcosis[J]. Vet Parasitol, 2013, 195(1/2): 131-135. |
/
| 〈 |
|
〉 |