The information on imported malaria cases and pidemiological case investigation in Linyi City, Shandong Province, from 2015—2021 were collected and analyzed. A total of 78 imported malaria cases were reported, including 65 cases of Plasmodium falciparum infection (83.3%), 11 cases of P. ovale infection (14.1%), 1 case of P. vivax infection (1.3%), and 1 case of P. malariae infection (1.3%). Among the reported cases, 1 case was imported from Myanmar (1.3%), and the remaining 77 cases were imported from African countries (98.7%). There was no obvious seasonal variation in the time of case reporting, but there were peaks in April, August, October and January; the main areas of case reporting were Hedong District (43 cases) and Lanshan District (16 cases) in Linyi City. The reported cases were all young and middle-aged males, with an average age of (41.03 ± 9.18) years old, and most cases were among the returned workers (68 cases). Among the reported cases, 38 were seen on the same day from the onset of symptoms, and the longest symptom-to-diagnosis interval was 30 days. All the reported cases had a history of overseas residence from 1 month to 3 years before the onset of the symptoms. The primary diagnosis and treatment units were mainly to medical units at the county level or below, accounting for 65.4% (51/78); the misdiagnosis rate of the initial diagnosis was 37.2% (29/78). 8 cases (10.3%) presented with complications. It is recommended to focus on providing health education on malaria prevention and control knowledge for labor exporting personnel, strengthen monitoring of mobile populations, and timely conduct pathogen screening and verification for personnel traveling to high malaria prevalence areas.