CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >

2023 , Vol. 41 >Issue 2: 219 - 222

DOI: https://doi.org/10.12140/j.issn.1000-7423.2023.02.015

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Research advances on the role and mechanism of neutrophil extracellular traps in parasitic infection

  • LI Chang ,
  • DU Xinyue ,
  • YAN Min ,
  • WANG Zhaojun
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  • 1 Department of Immunology and Microbiology, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    2 School of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
    3 Department of Microbiology and Immunology, Kunming Medical University, Kunming 650500, Yunnan, China
*E-mail: zjwang@sjtu.edu.cn

Received date: 2022-07-25

  Revised date: 2022-09-16

  Online published: 2023-04-07

Supported by

National Natural Science Foundation of China(NSF-81971486);National Natural Science Foundation of China(82272362)

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Abstract

Neutrophil extracellular traps (NETs) are neutrophil-derived extracellular net-like structures that are composed of chromatin and granule proteins. Initial reports demonstrated that the infection of parasites like protozoa and helminths could induce NETs formation, which plays important roles in the immune defence against parasites and immunopathology caused by infection. This review described the mechanisms of NETs formation and the role of NETs in protozoan and helminth infection, which provides new ideas for the prevention and treatment of parasitic diseases.

Key words： Neutrophil; Neutrophil extracellular trap; Protozoan infection; Helminth infection

Cite this article

LI Chang , DU Xinyue , YAN Min , WANG Zhaojun . Research advances on the role and mechanism of neutrophil extracellular traps in parasitic infection[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023 , 41(2) : 219 -222 . DOI: 10.12140/j.issn.1000-7423.2023.02.015

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