CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >

2023 , Vol. 41 >Issue 2: 213 - 218

DOI: https://doi.org/10.12140/j.issn.1000-7423.2023.02.014

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Research progress on molecular markers and epidemiology of Echinococcus ortleppi

  • SUN Hui ,
  • LI Li ,
  • YAN Hongbin ,
  • LI Xiurong ,
  • FU Baoquan ,
  • JIA Wanzhong
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  • 1 National Professional Laboratory for Animal Echinococcosis, Lanzhou 730046, Gansu, China
    2 Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease, Yangzhou 225009, China
*E-mail: jiawanzhong@caas.cn

Received date: 2022-07-18

  Revised date: 2022-09-12

  Online published: 2023-05-10

Supported by

National Key Research and Development Program of China(2021YFE0191600);Program of the State Key Laboratory of Veterinary Etiological Biology(SKLVEB2020CGPY01)

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Abstract

Echinococcosis is an important zoonotic parasitic disease caused by the metacestode stage larval of the genus Echinococcus. In China, it is mainly endemic in the western region. E. ortleppi is a unique specie of Echinococcus, due to its morphological and developmental characteristics, which are significantly different from that of E. granulosus. Its suitable intermediate host is cattle. Humans, pigs, camels, sheep, goats, lemurs and deers can be infected with E. ortleppi. In this review, the morphology, genetic variation, molecular genetic markers and epidemiology of E. ortleppi were summarized to provide a reference for epidemiological investigation, prevention and control and monitoring of echinococcosis.

Key words： Echinococcus ortleppi; Molecular genetic makers; Epidemiology

Cite this article

SUN Hui , LI Li , YAN Hongbin , LI Xiurong , FU Baoquan , JIA Wanzhong . Research progress on molecular markers and epidemiology of Echinococcus ortleppi[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2023 , 41(2) : 213 -218 . DOI: 10.12140/j.issn.1000-7423.2023.02.014

References

[1] Eckert J, Deplazes P. Biological, epidemiological, and clinical aspects of echinococcosis, a zoonosis of increasing concern[J]. Clin Microbiol Rev, 2004, 17(1): 107-135.
[2] Andrew Thompson RC, McManus DP. Towards a taxonomic revision of the genus Echinococcus[J]. Trends Parasitol, 2002, 18(10): 452-457.
[3] Obwaller A, Schneider R, Walochnik J, et al. Echinococcus granulosus strain differentiation based on sequence heterogeneity in mitochondrial genes of cytochrome coxidase-1 and NADH dehydrogenase-1[J]. Parasitology, 2004, 128(Pt5): 569-575.
[4] Romig T, Ebi D, Wassermann M. Taxonomy and molecular epidemiology of Echinococcus granulosus sensu lato[J]. Vet Parasitol, 2015, 213(3/4): 76-84.
[5] Ortlepp R. Echinococcus in dogs from Pretoria and vicinity[J]. Onderstepoort J Vet Res, 1934, 3: 97-108.
[6] Sharma M, Fomda BA, Mazta S, et al. Genetic diversity and population genetic structure analysis of Echinococcus granulosussensu stricto complex based on mitochondrial DNA signature[J]. PLoS One, 2013, 8(12): e82904.
[7] Balbinotti H, Santos GB, Badaraco J, et al. Echinococcus ortleppi(G5) and Echinococcus granulosus sensu stricto (G1) loads in cattle from Southern Brazil[J]. Vet Parasitol, 2012, 188(3/4): 255-260.
[8] Pednekar RP, Gatne ML, Andrew Thompson RC, et al. Molecular and morphological characterisation of Echinococcus from food producing animals in India[J]. Vet Parasitol, 2009, 165(1/2): 58-65.
[9] Sharbatkhori M, Harandi MF, Mirhendi H, et al. Sequence analysis of cox1 and nad1 genes in Echinococcus granulosus G3 genotype in camels (Camelus dromedarius) from central Iran[J]. Parasitol Res, 2011, 108(3): 521-527.
[10] Zhang LH, Joshi DD, McManus DP. Three genotypes of Echinococcus granulosus identified in Nepal using mitochondrial DNA markers[J]. Trans Royal Soc Trop Med Hyg, 2000, 94(3): 258-260.
[11] Denk D, Boufana B, Masters NJ, et al. Fatal echinococcosis in three lemurs in the United Kingdom: a case series[J]. Vet Parasitol, 2016, 218: 10-14.
[12] Boufana B, Stidworthy MF, Bell S, et al. Echinococcus and Taenia spp. from captive mammals in the United Kingdom[J]. Vet Parasitol, 2012, 190(1/2): 95-103.
[13] Nakao M, Yanagida T, Okamoto M, et al. State-of-the-art Echinococcus and Taenia: phylogenetic taxonomy of human-pathogenic tapeworms and its application to molecular diagnosis[J]. Infect Genet Evol, 2010, 10(4): 444-452.
[14] Andrew Thompson RC, Kumaratilake LM, Eckert J. Observations on Echinococcus granulosus of cattle origin in Switzerland[J]. Int J Parasitol, 1984, 14(3): 283-291.
[15] Verster AJ. Review of Echinococcus species in South Africa[J]. Onderstepoort J Vet Res, 1965, 32: 7-118.
[16] Jia WZ. Echinococcosis[M]. Beijing: China Agricultural Press, 2015: 45-120. (in Chinese)
  (贾万忠. 棘球蚴病[M]. 北京: 中国农业出版社, 2015: 45-120.)
[17] Brown WM, George M Jr, Wilson AC. Rapid evolution of animal mitochondrial DNA[J]. Proc Natl Acad Sci USA, 1979, 76(4): 1967-1971.
[18] Avila HG, Mozzoni C, Trangoni MD, et al. Development of a copro-LAMP assay for detection of several species of Echinococcus granulosus sensu lato complex[J]. Vet Parasitol, 2020, 277: 109017.
[19] Hüttner M, Nakao M, Wassermann T, et al. Genetic characterization and phylogenetic position of Echinococcus felidis (Cestoda:Taeniidae) from the African lion[J]. Int J Parasitol, 2008, 38(7): 861-868.
[20] (HidalgoA, Melo A, Romero F, et al. A PCR-RFLP assay for discrimination of Echinococcus granulosus sensu stricto and Taenia spp. in dogs stool[J]. Exp Parasitol, 2019, 200: 42-47.
[21] Maksimov P, Bergmann H, Wassermann M, et al. Species detection within the Echinococcus granulosus sensu lato complex by novel probe-based real-time PCRs[J]. Pathogens, 2020, 9(10): 791.
[22] Wang HP, Li X, Sun SJ. Detection of Echinococcus granulosus in sheep liver from Kashi region of Xinjiang by degenerate primer q-PCR method[J]. Guangdong Med J, 2022, 43(1): 46-50. (in Chinese)
  (王会品, 李欣, 孙世珺. 简并引物q-PCR法检测新疆喀什地区羊肝组织中细粒棘球绦虫[J]. 广东医学, 2022, 43(1): 46-50.)
[23] Yang D, Liu AQ, Zhao W, et al. Research progress on classification and classification of Echinococcus granulosus[J]. J Trop Med, 2015, 15(9): 1296-1299. (in Chinese)
  (杨东, 刘爱芹, 赵威, 等. 细粒棘球绦虫分型和分类研究进展[J]. 热带医学杂志, 2015, 15(9): 1296-1299.)
[24] Fan YL, Lou ZZ, Li L, et al. Research progress on methods for the classification and identification of cestodes[J]. Chin J Zoonoses, 2014, 30(2): 199-206. (in Chinese)
  (范彦雷, 娄忠子, 李立, 等. 绦虫种的分类鉴定方法研究进展[J]. 中国人兽共患病学报, 2014, 30(2): 199-206.)
[25] McManus DP, Rishi AK. Genetic heterogeneity within Echinococcus granulosus: isolates from different hosts and geographical areas characterized with DNA probes[J]. Parasitology, 1989, 99 Pt 1: 17-29.
[26] Ma XM, Ding JB, Yi TL, et al. Application of molecular biological techniques for classification of Echinococcus granulosus strains[J]. Mod Prev Med, 2009, 36(10): 1911-1913, 1929. (in Chinese)
  (马秀敏, 丁剑冰, 伊藤亮, 等. 分子生物学技术在细粒棘球绦虫虫株分类研究中的应用[J]. 现代预防医学, 2009, 36(10): 1911-1913, 1929.)
[27] Wei YH, Hu Y, Cao JP. Advances in the genetic polymorphism of Echinococcus granulosus[J]. Chin J Parasitol Parasit Dis, 2019, 37(4): 481-485. (in Chinese)
  (魏玉环, 胡媛, 曹建平. 细粒棘球绦虫基因多态性的研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2019, 37(4): 481-485.)
[28] Maillard S, Gottstein B, Haag KL, et al. The EmsB tandemly repeated multilocus microsatellite: a new tool to investigate genetic diversity of Echinococcus granulosus sensu lato[J]. J Clin Microbiol, 2009, 47(11): 3608-3616.
[29] Bowles J, Blair D, McManus DP. Genetic variants within the genus Echinococcus identified by mitochondrial DNA sequencing[J]. Mol Biochem Parasitol, 1992, 54(2): 165-173.
[30] Maravilla P, Andrew Thompson RC, Palacios-Ruiz JA, et al. Echinococcus granulosus cattle strain identification in an autochthonous case of cystic echinococcosis in central Mexico[J]. Acta Trop, 2004, 92(3): 231-236.
[31] Karamon J, Samorek-Pieróg M, Sroka J, et al. The first record of Echinococcus ortleppi (G5) tapeworms in grey wolf (Canis lupus)[J]. Pathogens, 2021, 10(7): 853.
[32] de la Rue ML, Takano K, Brochado JF, et al. Infection of humans and animals with Echinococcus granulosus (G1 and G3 strains) and E. ortleppi in Southern Brazil[J]. Vet Parasitol, 2011, 177(1/2): 97-103.
[33] Corrêa F, Stoore C, Horlacher P, et al. First description of Echinococcus ortleppi and cystic echinococcosis infection status in Chile[J]. PLoS One, 2018, 13(5): e0197620.
[34] Cucher MA, Macchiaroli N, Baldi G, et al. Cystic echinococcosis in South America: dystematic review of species and genotypes of Echinococcus granulosus sensu lato in humans and natural domestic hosts[J]. Trop Med Int Health, 2016, 21(2): 166-175.
[35] Kamenetzky L, Gutierrez AM, Canova SG, et al. Several strains of Echinococcus granulosus infect livestock and humans in Argentina[J]. Infect Genet Evol, 2002, 2(2): 129-136.
[36] Ali V, Martinez E, Duran P, et al. Echinococcus granulosussensu stricto Echinococcus ortleppi; and E. intermedius (G7) are present in Bolivia[J]. Parasitology, 2020, 147(9): 949-956.
[37] Casulli A, Manfredi MT, La Rosa G, et al. Echinococcus ortleppi and E. granulosus G1, G2 and G3 genotypes in Italian bovines[J]. Vet Parasitol, 2008, 155(1/2): 168-172.
[38] Grenouillet F, Umhang G, Arbez-Gindre F, et al. Echinococcus ortleppi infections in humans and cattle, France[J]. Emerg Infect Dis, 2014, 20(12): 2100-2102.
[39] Deplazes P, Rinaldi L, Alvarez Rojas CA, et al. Global distribution of alveolar and cystic echinococcosis[J]. Adv Parasitol, 2017, 95: 315-493.
[40] Dybicz M, Borkowski PK, Jonas M, et al. First report of Echinococcus ortleppi in human cases of cystic echinococcosis in Poland[J]. Biomed Res Int, 2019, 2019: 2474839.
[41] Bowles J, van Knapen F, McManus D. Cattle strain of Echinococcus granulosus and human infection[J]. Lancet, 1992, 339(8805): 1358.
[42] Sharma M, Sehgal R, Fomda BA, et al. Molecular characterization of Echinococcus granulosus cysts in North Indian patients: identification of G1, G3, G5 and G6 genotypes[J]. PLoS Negl Trop Dis, 2013, 7(6): e2262.
[43] Thapa NK, Armua-Fernandez MT, Kinzang D, et al. Detection of Echinococcus granulosus and Echinococcus ortleppi in Bhutan[J]. Parasitol Int, 2017, 66(2): 139-141.
[44] Van De N, Le Van D. The first report of two cases of cystic echinococcosis in the lung by Echinococcus ortleppi infection, in Vietnam[J]. Res Rep Trop Med, 2017, 8(3): 45-51.
[45] Shi YL, Wan XL, Wang ZY, et al. First description of Echinococcus ortleppi infection in China[J]. Parasit Vectors, 2019, 12(1): 398.
[46] Alvi MA, Ohiolei JA, Saqib M, et al. Echinococcus granulosus sensu stricto(G1, G3) and E. ortleppi (G5) in Pakistan: phylogeny, genetic diversity and population structural analysis based on mitochondrial DNA[J]. Parasit Vectors, 2020, 13(1): 347.
[47] Gholami S, Behrestaghi LE, Sarvi S, et al. First description of the emergence of Echinococcus ortleppi (G5 genotype) in sheep and goats in Iran[J]. Parasitol Int, 2021, 83: 102316.
[48] Avcioglu H, Guven E, Balkaya I, et al. The situation of echinococcosis in stray dogs in Turkey: the first finding of Echinococcus multilocularis and Echinococcus ortleppi[J]. Parasitology, 2021, 148(9): 1092-1098.
[49] Amer S, Helal IB, Kamau E, et al. Molecular characterization of Echinococcus granulosus sensu lato from farm animals in Egypt[J]. PLoS One, 2015, 10(3): e0118509.
[50] Ahmed ME, Eltom KH, Musa NO, et al. First report on circulation of Echinococcus ortleppi in the one humped camel (Camelus dromedaries), Sudan[J]. BMC Vet Res, 2013, 9: 127.
[51] Tigre W, Deresa B, Haile A, et al. Molecular characterization of Echinococcus granulosus s. l. cysts from cattle, camels, goats and pigs in Ethiopia[J]. Vet Parasitol, 2016, 215: 17-21.
[52] Addy F, Alakonya A, Wamae N, et al. Prevalence and diversity of cystic echinococcosis in livestock in Maasailand, Kenya[J]. Parasitol Res, 2012, 111(6): 2289-2294.
[53] Addy F, Wassermann M, Banda F, et al. Genetic polymorphism and population structure of Echinococcus ortleppi[J]. Parasitology, 2017, 144(4): 450-458.
[54] Nematdoost K, Ashrafi K, Majidi-Shad B, et al. Genetic characterization of Echinococcus granulosus sensu lato in livestock and human isolates from north of Iran indicates the presence of E. ortleppi in cattle[J]. Acta Parasit, 2021, 66(2): 446-454.
[55] Alvarez Rojas CA, Gauci CG, Lightowlers MW. Antigenic differences between the EG95-related proteins from Echinococcus granulosus G1 and G6 genotypes: implications for vaccination[J]. Parasite Immunol, 2013, 35(2): 99-102.
[56] Bart JM, Abdukader M, Zhang YL, et al. Genotyping of human cystic echinococcosis in Xinjiang, PR China[J]. Parasitology, 2006, 133(Pt 5): 571-579.
[57] Zhang TM, Yang D, Zeng ZL, et al. Genetic characterization of human-derived hydatid cysts of Echinococcus granulosus sensu lato in Heilongjiang Province and the first report of G7 genotype of E. canadensis in humans in China[J]. PLoS One, 2014, 9(10): e109059.
[58] Yang D, Zhang TM, Zeng ZL, et al. The first report of human-derived G10 genotype of Echinococcus canadensis in China and possible sources and routes of transmission[J]. Parasitol Int, 2015, 64(5): 330-333.
[59] Mulinge E, Magambo J, Odongo D, et al. Molecular characterization of Echinococcus species in dogs from four regions of Kenya[J]. Vet Parasitol, 2018, 255: 49-57.
[60] Basmaciyan L, Burlet B, Ramla S, et al. First case of human primary vertebral cystic echinococcosis due to Echinococcus ortleppi[J]. J Clin Med, 2018, 7(11): 443.
[61] Hod?i? A, Ali? A, ?upi? J, et al. Echinococcus ortleppi, the cattle strain in a crested porcupine (Hystrix cristata): a new host record[J]. Vet Parasitol, 2018, 256: 32-34.
[62] Pourseif MM, Moghaddam G, Saeedi N, et al. Current status and future prospective of vaccine development against Echinococcus granulosus[J]. Biologicals, 2018, 51: 1-11.
[63] Banda F, Sikasunge C, Addy F, et al. Echinococcus ortleppi and Echinococcus canadensis G6/7 affect domestic animals in western Zambia[J]. Acta Trop, 2020, 211: 105648.
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