CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >
Research progress of immune regulation protein B7 family on immune regulation during Schistosoma japonicum infection
Received date: 2022-05-11
Revised date: 2022-06-13
Online published: 2022-12-26
Supported by
National Natural Science Foundation of China(82172295);National Natural Science Foundation of China(81871677)
Schistosomiasis japonica is one of the most serious zoonotic diseases in the world. After schistosome infection, Th1 cells secrete interferon-γ (IFN-γ), tumour necrosis factor-α (TNF-α), and CD8+ T cells exert cellular immunity at the early stage. Th2 cells secrete a large amount of interleukin-4 (IL-4), interleukin-13 (IL-13) and interleukin-12 (IL-12), and the function of Th1 cells is inhibited in the later stage, thus prompting the host to produce an adaptive immune response dominated by humoral immunity. The B7 family is a secondary signal of T cell activation and plays a crucial role in regulating T cell immune responses. Further studies demonstrate that B7 family contains B7-1, B7-2, B7 homologue1 (B7-H1), B7 dendritic cell molecule (B7-DC), B7-H2, B7-H3, B7-H4, B7-H5, B7-H6 and B7-H7, which have costimulatory or coinhibitory effects on T cells. Some of them play an important role in immune regulation in schistosomiasis and the research progress of the B7 family in the immune regulation during schistosome infection is summarised in this paper.
Key words： Schistosoma japonicum; B7 family; Immune regulation
CHEN Guo , ZHU Dan-dan , DUAN Yi-nong . Research progress of immune regulation protein B7 family on immune regulation during Schistosoma japonicum infection[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022 , 40(6) : 774 -779 . DOI: 10.12140/j.issn.1000-7423.2022.06.013
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