CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >
Advances in research on the vacuolar membrane function and the associated proteins of plasmodium parasitophorous vacuole
Received date: 2021-09-30
Revised date: 2022-01-17
Online published: 2022-07-06
Supported by
National Nature Science Foundation of China(81871681)
Malaria is one of the most important infectious diseases in the world and seriously threatens human health. It remains a critical problem to interrupt malaria transmission. Plasmodium parasites invade and multiply inside the host cells causing severe pathological damage to the host. As the interface between the host cells and Plasmodium parasites, PVM is of crucial importance for the survival of Plasmodium parasites. This manuscript briefly introduces the formation of PVM and its relationship with PPM and TVN. The PVM-associated proteins and their functions in blood-stage, liver-stage and sexual-stage parasites are summarized. This review also presents perspectives on malaria control strategies.
Key words： Plasmodium; PVM; Membrane protein; Malaria
GE Jie-yun , LIU Lei , SUN Yi-fan , CHENG Yang . Advances in research on the vacuolar membrane function and the associated proteins of plasmodium parasitophorous vacuole[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022 , 40(3) : 402 -410 . DOI: 10.12140/j.issn.1000-7423.2022.03.019
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