In October 2019, Guizhou Center for Disease Control and Prevention received a report of one imported case of malaria. The patient worked in the outdoor advertising business in Coate d’Ivoire from April 2018 to October 2019. No other anti-mosquito measures were taken except for mosquito coil incense. During this period, the patient was infected with malaria twice. On admission, the patient was in coma with jaundice, shortness of breath and brain damage, ARDS, shock, severe anemia, acidosis, and other complications. Plasmodium antigen tests were positive. Ring forms, trophozoites, merozoites and gametocytes were found in blood smears. Nested PCR showed positive for Plasmodium falciparum bands. P. falciparum malaria diagnosis was made based on the epidemiological history and laboratory test results. Standard antimalarial treatment was given to the patient, and the parasitemia was monitored. Administration of the anti-malarial drugs was effective. The patient did not report any symptoms over the follow-up period.