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Research progress on signal pathways related to host T cell immune response in helminth infection
Received date: 2021-08-12
Revised date: 2021-09-17
Online published: 2022-03-30
Supported by
National Natural Science Foundation of China(81960378)
Helminthiasis is highly prevalent in Asia, Africa and South America, seriously affecting human health and economic development. Helminths infection can initiate host T cell immune response, thereby affecting T cell proliferation and differentiation. Some data indicate that in helminth infection, signalling pathways including transforming growth factor-β/Smad(TGF-β/Smad), inducible costimulator-inducible costimulator ligands (ICOS-ICOSL), programmed cell death protein-1/programmed death protein-1 ligand (PD-1/PD-L1), toll-like receptors/myeloid differentiation factor 88 (TLRs/MyD88). can participate in host T cell immune response, the interaction between signalling molecules can induce T cell proliferation and differentiation, then affect the host T cells to play an role in anti-worm infection effect. This article has reviewed the research advances on T cell immune response-related signalling pathways in worm infection.
Key words： Helminth; Cellular immune response; Signalling pathway
HE Wei , ZHOU Bi-ying . Research progress on signal pathways related to host T cell immune response in helminth infection[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022 , 40(2) : 223 -227 . DOI: 10.12140/j.issn.1000-7423.2022.02.014
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