With the emergence of the global health concept, there are arising some questions for parasitology teaching that need to be urgently addressed, including how to reflect innovation, high performance and challenges, how to train students’ scientific view on health, how to enhance students’ application, analysis, evaluation and innovation capabilities, and how to promote an international perspective and strengthen mission responsibility among students. The “Belt and Road Initiative and global health” course may help college students to focus on the major health issues of global health. We integrated Belt and Road Initiative education into human parasitology teaching and carried out teaching practice. We integrated parasitology into the category of “pathogen biology” to cultivate students′ holistic view, integrated parasitology into the field of “global health” to cultivate students’ global outlook, and immersed parasitology theory into the whole process of “social practice”, so that students can apply what they have learned. This teaching strategy can improve the teaching effect and cultivate qualified medical workers for China and the whole world.