To analyze malaria situation and epidemiological characteristics in Nanchang from 2014 to 2018, and to provide scientific reference for formulation of a rational malaria control strategy in the city, the information of malaria cases and associated epidemiological data of Nanchang City from 2014 to 2018 were collected from the National Infectious Disease Report Information Management System and the Nanchang Malaria Epidemic Information Sheet and Epidemic Case Survey Form. The ArcGIS 10.1 software was used to analyze the spatial distribution of malaria cases. From 2014 to 2018, a total of 114 malaria cases were reported in Nanchang, all of them were imported cases from countries outside of China. Among them, 110 cases (96.49%) were imported from African countries, 3 cases (2.63%) from Asian countries, and 1 case (0.88%) from an Oceania country.Plasmodium infection was predominated by P. falciparum (65 cases, 57.02%) and P. vivax (30 cases, 26.32%); the cases were reported throughout the months, with no obvious seasonal changes. The malaria cases comprised 107 males (93.86%) and 7 females (6.14%), with male-to-female ratio of 15.3: 1; and the average age of the disease occurrence was 39.81 years. In addition, 111 of the cases (97.37%) were distributed in the age groups of 20-39 and 40-59. The occupation distribution were predominated by workers (44, 38.59%) and farmers (37, 32.46%). The median time from onset to etiological diagnosis was 3 days. No recurrence, re-ignition, death, and imported secondary cases occurred. Jinxian County, Qingshan Lake District, and Xinjian District were the top three counties in Nanchang City in terms of reported malaria cases. ArcGIS10.1 hotspot map showed that Nanchang urban area and Jinxian County were two concentrated spots. These results suggest that prevention and control of imported malaria is the key point of future work in Nanchang City, with Jinxian County as a particular key site.