CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >
Research progress on the mechanisms underlying the impairment of host hepatocytes by Echinococcus multilocularis
Received date: 2020-06-11
Revised date: 2020-10-24
Online published: 2021-04-30
Supported by
Qinghai Province Talent Project;Chinese Academy of Sciences “Western Light” (young scholars)Project;Qinghai University Affiliated Hospital Key Project of Research Funds for Young and Middle-age Researchers(ASRF-2016-01)
Copyright
Alveolar echinococcosis is a disease caused by infection of Echinococcus multilocularis metacestode, which leads to severe clinical symptoms with high mortality. This disease develops from the host liver, damaging hepatocytes. E. multilocularis metacestode infection could affect the expression of hepatocyte collagen gene, cell cycle alteration, mediation of host immune responses, activation of signaling pathways and expression of related genes. This paper reviews the mechanisms damaging the host hepatocytes to provide useful reference information for treatment of alveolar echinococcosis.
XU Kai , WANG Hai-jiu , ZHANG Li , ZHANG Yao-gang , FAN Hai-ning , REN Li , REN Bin , WANG Zhi-xin . Research progress on the mechanisms underlying the impairment of host hepatocytes by Echinococcus multilocularis[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2021 , 39(2) : 256 -259 . DOI: 10.12140/j.issn.1000-7423.2021.02.020
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