CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES >
Advances in research on exosomes of Toxoplasma spp.
Received date: 2020-02-22
Online published: 2020-11-12
Supported by
National Natural Science Foundation of China(81702025);Science and Technology Project of Henan Province(182102310220);Doctoral Research Fund of Xinxiang Medical University(XYBSKYZZ201504)
Exosomes are a type of extracellular vesicles secreted by a variety of cells, and contain many active components such as proteins, lipids, and nucleic acids. Studies have shown that a majority of parasites can secrete exosomes, which play important roles in mediating communications between parasites and host cells, regulating host immune responses, as well as transmitting pathogenic factors, drug resistance-associated genes and differentiation factors. In addition, exosome-based therapies and vaccine development are still under the way. In this paper, we summarize the biological characteristics and functions of exosomes secreted by Toxoplasma spp., and discuss their application potentials.
Key words： Toxoplasma; Exosome; Immunomodulation; Application
Peng-ju LI , Su-qiong ZUO , Yu-juan DUAN , Hao-ran LI , Zhen-chao ZHANG , Xiang-rui LI , Shuai WANG . Advances in research on exosomes of Toxoplasma spp.[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2020 , 38(5) : 653 -657 . DOI: 10.12140/j.issn.1000-7423.2020.05.020
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