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Research progress on the anti-tumor effects of Toxoplasma gondii and the underlying mechanisms
Received date: 2019-11-27
Online published: 2020-09-09
Supported by
National Natural Science Foundation of China(81702025);Science and Technology Project of Henan Province(182102310220)
Toxoplasma gondii is an important opportunistic pathogenic protozoan and is a big threat to human health. However, studies have revealed significant anti-tumor effects of the T. gondii parasite, as well as its culture supernatant or excretory secretory antigen, antigen lysate, and secreted proteins. In the mechanism of the anti-tumor effects, the induction of tumor cell apoptosis, inhibition of tumor tissue neovascularization and enhancement of the function of host immune cells play crucial roles. In this review, we summarize research progress on the anti-tumor effects of T. gondii and the mechanisms in association with the parasite and its related components.
Key words： Toxoplasma gondii; Anti-tumor effect; Cancer treatment; Effector component
Fu-qiang ZHANG , Jiao-jiao QIAO , Hao-ran LI , Zhen-chao ZHANG , Xiang-rui LI , Shuai WANG . Research progress on the anti-tumor effects of Toxoplasma gondii and the underlying mechanisms[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2020 , 38(4) : 496 -502 . DOI: 10.12140/j.issn.1000-7423.2020.04.017
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