Research development on non-coding RNA of Plasmodium falciparum

Abstract

Abstract:

Malaria remains among the top three infectious diseases in the world and poses a serious threat to human health. Among the five Plasmodium species that cause human malaria, Plasmodium falciparum has the highest virulence and is the most lethal one. It has been shown that the immune evasion of parasites is closely related to the mutually exclusive expression of antigen-coding genes in P. falciparum, which depends on the precise gene regulatory mechanism. There are a large number of non-coding RNAs (ncRNAs) in P. falciparum, and some of them have been found to play a vital role in gene expression during parasite development and in pathogenesis. In this review we summarize recent findings on functions of P. falciparum-related ncRNAs, in order to advance our understanding of the regulation of Plasmodium gene expression and provide a theoretical basis for studies on molecular mechanism of Plasmodium pathogenesis.

Key words: Malaria, Plasmodium falciparum, Non-coding RNA

CLC Number:

R382.312

Zhi-hua WANG, Chun-yan WEI, Heng WANG. Research development on non-coding RNA of Plasmodium falciparum[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2018, 36(4): 409-413.

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