Abstract: 　Objective To explore the in vitro effect of cyclosporine A on the tegument of juvenile Schistosoma mansoni labeled by AF18 and investigate the effect of cyclosporine A on schistosomula surface membrane fluidity. Methods Preparation of transformed schistosomula, adding cyclosporine A into tubes containing schistosomula and labeling of transformed schistosomula with AF18,then observe schistosomula under fluorescence microscope. Results Schistosomula of different groups labeled by AF 18 were damaged by cyclosporine A in vitro. Conclusion Cyclosporine A increases the uptake of AF18 by schistsomula in vitro which is dose-dependent, and decreases the parasite surface membrane fluidity.

Key words: Schistosoma mansoni, Cyclosporine A, Schistosomula, AF18