Abstract: This article presents the application of ELISA to liver sections of infected mice containing schistosomal egg granuloma as antigen to detect the specific antibody in sera of schistosomiasis patients. 56 sera from patients with acute (35) and chronic(21) schistosomiasis japonica were all positive, while 3 of 6 patients with advanced schistosomiasis showed positive. No false positive reaction was found in 50 controls. The technique appears quite sensitive and specific in the diagnosis of schistosomiasis japonica.