Abstract: Pyquiton was given in a single dose of 20, 10 and 5mg/kg to 15, 17 and 17 patients with Echinochasmus japonicus infection respectively. 7-10 days after treatment the cure rates of the treated groups were 93.3%, 94.1% and 100% respectively. After 1 month, the cure rates were 86.7%, 94.1% and 100%. In addition, one patient who was given a single dose of 2mg/kg was found egg negative 7-10 days after treatment but became egg positive after one month. The drug was well tolerated. The preliminary results showed that pyquiton was highly effective with mild side effects in the treatment of Echinochasmus japonicus infection.