Abstract: Re-evaluation of latex agglutination test to detect the anti-schistosome antibody showed that the covalently bounded latex-egg antigen was highly sensitive and specific. The positive rates in 143 chronic and 32 acute schistosomiasis japonica patients were 89.5% and 93.8% respectively. All sera from 92 blood donors from Beijing and 142 blood donors from Atlanta, U. S. A. were negative, yet a false positive rate of 3% was found among 100 inhabitants in Shanghai. Covalently bounded latex-egg antigen cross-reacted with sera from patients of schistosomiasis mansoni and schistosomiasis haematobium, the cross reaction rates being 40.5% (17/42) and 45.5% (5/11) respectively. 7.7-10% cross reactions were found with sera from patients of filariasis clonorchiasis and paragonimiasis. It was found that covalently bounded latex agglutination test was a simple, rapid and reproducible method. It was easy to perform and suitable for field use.