Abstract: Fourty-eight falciparam malaria cases were treated by pyronaridine phosphate (1.2 S base) jointly with sulfadimoxine (1g) and primaquine phosphate (45 mg base) in 2 days in Mengla County, Yunnan Province, where chioroquine-resistant Plasmodium falciparum is endemic. 36 falciparum malaria cases were treated with pyronaridine (1.2 g) alone. The average defervescence time of the combined treatment group and the pyronaridine group was 32 ±16 h and 32.7±16h; the mean asexual parasite clearance time of the groups was 59±20.8 h and 64 ± 22.9 h respectively. During 1 month follow-up, the asexual parasite recrudescence irate of the 2 groups was 2.5% and 15.2%; the gametocyte-carrying rate was 50.0% (19/38) and 93.9% (31/33). No marked side effects were observed in the co-mbined therapy.