Abstract: Mice infected in our laboratory with Ancylostoma duodenale were used to evaluate the effect of levamisole, albendazole, pyquiton, mebendazole and amidantel against the migrating stage larvae. The results showed that levamisole 34 mg/kg·d×3 and albendazole 181.4mg/kg·d×5 exerted promising effect and the reduction rates of larvae were as high as 97.3% and 97.5% respectively.It is recommended that levamisole and albendazole could be used in field trials to control both adults and migrating larvae of A. duodenale.