Abstract: The pathological features of liver biopsy and HBV markers (ihcluding serum HBsAg, anti-HBc, anti-HBs and Orcein stain of HBsAg) were studied in 100 clinically diagnosed advanced schistosomiasis cases and correlative analysis was made with clinical data.The results showed that out of 100 cases twelve cases were pathologically diagnosed as simple schistosomiasis, 53 cases as schistosomiasis accompanied with chronic hepatitis B, and 35 as simple chronic hepatitis B.Histological Identification of the 53 cases of schistosomiasis accompanied with chronic hepatitis was classified as light hepatitis in 15, chronic prolonged hepatitis in 14, chronic active hepatitis in 5, and chronic active hepatitis with post-hepatic cirxhosis in 19 (35.8%). indicating that the liver damage in majority of clinically diagnosed schistosomiasis was due to HBV. A positive rate of HBV markers as high as 67.1% in serum and 38% of positive Orcein stain of HBsAg in liver biopsy are supportive to this argument.The possible relationship of HBV infection in advanced schistosomiasis patients to blood transfusion and the possible immune suppression mechanism are discussed.