CHARACTERIZATION OF A SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM MEROZOITE WITH MONOCLONAL ANTIBODY

›› 1992, Vol. 10 ›› Issue (3): 184-186.

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CHARACTERIZATION OF A SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM MEROZOITE WITH MONOCLONAL ANTIBODY

  

  • Online:1992-08-31 Published:2017-01-09

Abstract: The monoclonal antibody (McAb) designated as C6 against erythrocytic stage of Plas-modium falciparum Fcc7801/HN showed significant growth inhibition of P.falciparum in vitro,having cross immunofluorescence reaction with P.falciparum Fcc-1/HN,Fcc7802/HN,Fcc8703/JS and P.berghei,P.cynomolgi.McAb C6 bound to the antigen distribured evenly over the entire surface of merozoites of P.falciparum,as demonstrated by immunoe:ectron microscopy.The McAb C6 also recognized a single protein of 71 kDa of P.falciparum by Western blotting.This antigen might be a candidate of malaria vaccine.