Abstract: The chemically synthesized hybrid genes HGFC and HGFCAC were respectively recombinated with expression vector pWR450 1 and transferred into Escherichia coli .After adding IPTG to the cultural media,the bacteria harboring recombinant plasmid expressed the fusion proteins of exogenous gene products and partial amino acid of β galactosidase.The molecular weights of the two fusion proteins were 65 kDa and 77 kDa,respectively.The expressed fusion proteins could be recognized by antibodies of rabbit anti RESA peptide EENVEHDA by Western blotting,indicating that the fusion proteins harbored the antigenic epitopes of Plasmodium falciparum .