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Application of DNA Microarray Technology in Human Trypanosomiasis Research

CHEN Mu-xin, CHEN Jia-xu*   

  1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory of Parasite and Vector Biology, Ministry of Health; National Center for International Research on Tropical Diseases, Ministry of Science and Technology; WHO Collaborating Centre for Tropical Diseases, Shanghai 200025, China
  • Online:2016-08-30 Published:2016-11-07
  • Supported by:

    Supported by the National Science and Technology Major Project （No. 2012ZX10004-220） and the National Key Technology Research and Development Program（No. 2008BAI56B03）

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Abstract:

With the rapid development of molecular biological techniques, DNA microarray has shown great advantage in biology and medicine as it allows high-throughput measurement of various biological parameters. Trypanosomiasis remains the focus among numerous human blood parasitic diseases. The DNA microarray is a useful technique for studying the trypanosome genome and parasite-host interaction, as well as for vaccine screening and drug development. This review gives an update on the application of DNA microarray in human research on Trypanosoma brucei and Trypanosoma cruzi.

Key words: DNA microarray, Human trypanosomiasis, Trypanosoma brucei, Trypanosoma cruzi