Abstract: In order to observe the efficacy of albendazole for the treatment of mice infected with Sparganum mansoni，a total of 72 mice were divided into 8 groups （9 mice each），each mouse was orally infected with 5 plerocercoid. At one week after infection，groups A-C were treated with a 7-day course of albendazole （1 700，2 500，and 3 300 mg/kg，twice daily），and sacrificed at 1 week post-treatment；groups E-G were treated with the second course of albendazole with the same dosage at 1 week interval after the first course，and sacrificed at 1 week after the second course；the groups D and H were used as control for A-C and E-G，respectively. After the infected mice were sacrificed，the mean number of worms recovered was observed and worm reduction rate was determined. When treating with one course of albendazole at 1 week post in-fection，the worm reduction rate in groups A-C was 20.0%，20.0% and 24.9%，respectively （χ²=0.351，P>0.05）. After treatment with two courses of albendazole，the worm reduction rate in groups E-G was 22.3%，36.4% and 31.9% （χ²=1.812，P>0.05）. The difference of the worm reduction rate in the infected mice treated with 1 and 2 courses of albendazole showed no statistical significance （P>0.05）. The results indicated albendazole has no obvious efficacy for treating sparganosis in mice.

Key words: Sparganum mansoni, Sparganosis, Treatment, Albendazole, Mouse