Research progress on acquired toxoplasmosis in immunocompetent individuals

doi:10.12140/j.issn.1000-7423.2022.02.015

Abstract

Abstract:

Although Toxoplasma gondii infection is usually asymptomatic in immunocompetent individuals, a small part of T. gondii-infected immunocompetent individuals may have mild or even severe clinical symptoms. Using the keywords “immunocompetent” “T. gondii” “toxoplasmosis” “diagnosis” and “treatment” in the PubMed and China National Knowledge Infrastructure (CNKI) search engines, the authors systematically searched the cases of acquired toxoplasmosis in immunocompetent individuals reported from 1984 to 2021. This review summarizes the clinical manifestation, pathogenesis, diagnosis, and treatment of acquired toxoplasmosis in immunocompetent individuals, to provide a reference for clinical differential diagnosis and treatment of toxoplasmosis.

Key words: Toxoplasmosis, Immunocompetent individual, Diagnosis, Treatment

CLC Number:

R531.8

ZHAO Zi-qi, LV Fang-li. Research progress on acquired toxoplasmosis in immunocompetent individuals[J]. CHINESE JOURNAL OF PARASITOLOGY AND PARASITIC DISEASES, 2022, 40(2): 228-235.

Figures/Tables 1

References 90

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特征	病例数/例
特征	眼弓形虫病（n = 16）	肺弓形虫病（n = 11）	脑弓形虫病（n = 19）	其他弓形虫病（n = 32）
性别
男	10	6	15	23
女	6	5	4	9
流行病学史
接触猫	2	1	2	4
接触鹿、熊、犬、野兔	3	-	1	1
食用生肉、半生肉	2	8	4	11
食用鹿、犰狳、豚鼠、野猪肉	-	-	-	7
其他	9	2	12	9
临床症状
发热	2	11	8	24
淋巴结肿大	1	4	3	15
头痛、肌痛	2	8	13	21
眼睛疼痛、漂浮物	8	-	-	-
视力下降	15	-	2	3
呼吸系统症状	2	15	5	17
神经系统症状	-	-	18	4
胸闷、胸痛	-	2	-	7
心肌炎、心包炎	1	-	-	11
多发性肌炎	1	-	-	9
肝炎	-	-	-	5
肾病综合征	-	-	-	2
风疹皮疹或丘疹	-	-	1	5
面神经麻痹	-	-	2	1
附睾炎睾丸炎	-	-	-	1
弓形虫血清学检测
IgM⁺/IgG⁺	7	5	5	26
IgM^-/IgG⁺	3	-	5	-
IgM⁺/IgG^-	-	1	-	3
IgM^-/IgG^-	1	-	2	1
IgM未知/IgG⁺	2	1	3	-
IgM⁺/IgG未知	-	3	1	-
未知	3	1	3	2
弓形虫PCR检测
阳性	7	2	3	6
阴性	-	-	2	4
未知	9	9	14	22
治疗药物
PY	-	-	-	1
PY + SDZ	-	1	3	4
PY + SDZ + LKV	4	4	3	8
TMP-SMX	6	2	2	3
TMP-SMX + PY	-	-	1	-
TMP-SMX + LKV	-	-	1	-
TMP-SMX + PY + LKV	2	-	1	-
TMP-SMX + PY + SDM	-	-	-	1
TMP-SMX + PY + SDZ	-	1	-	1
TMP-SMX + PY + SDZ + LKV	3	-	1	2
SPM	-	1	-	1
SPM + PY	-	1	-	1
SPM + SDZ	-	-	1	-
SPM + PY + SDZ	-	1	-	-
SPM + PY + SDZ + LKV	-	-	1	-
Ac-SPM + PY	1	-	-	-
Ac-SPM + PY + SDZ	-	-	1	-
CS/ATB/ATB + CS	-	-	3	6
其他	-	-	1	4
预后
存活	16	11	15	31
死亡	0	0	4	1
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