Screening for relevant proteins involved in adhesion of Cryptosporidium parvum sporozoites to host cells

›› 2009, Vol. 27 ›› Issue (1): 21-88.

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Screening for relevant proteins involved in adhesion of Cryptosporidium parvum sporozoites to host cells

GUO An1,YIN Ji-gang1 *,XIANG Mei2,LIU Xian-ying2,ZHANG Yan1，CHEN Qi-jun1

1 Key Laboratory of Zoonosis，Ministry of Education，Institute of Zoonosis，Jilin University，Changchun 130062，China；2 Department of Obstetrics and Gynecology，The Second Hospital，Jilin University，Changchun 130041，China

Received:1900-01-01 Revised:1900-01-01 Online:2009-02-28 Published:2009-02-28
Contact: YIN Ji-gang

Abstract

Abstract: The Cryptosporidium parvum T7 phage display library was screened by using Caco-2 cells. Five specific gene fragments were identified by blasting sequences in GenBank， one of which encoding the CP2 protein was previously identified as a surface molecule of sporozoites and involved in parasite invasion. The others are hypothetic proteins with unknown functions. Bioinformatic analysis of these proteins indicated that they may be involved in the host-parasite interactions.

Key words: Cryptosporidium parvum, T7 phage display, Screening, Adhesion

GUOAn;YINJi-gang*;XIANGMei;LIUXian-ying;ZHANGYan;CHENQi-jun. Screening for relevant proteins involved in adhesion of Cryptosporidium parvum sporozoites to host cells[J]. , 2009, 27(1): 21-88.

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Screening for relevant proteins involved in adhesion of Cryptosporidium parvum sporozoites to host cells

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