关键词: 日本血吸虫, 代谢产物, 脾淋巴细胞, 感染小鼠, 免疫应答, 童虫, 淋巴细胞应答, 可溶性虫卵抗原, 应答能力, 寄生虫病研究所

Abstract: The effects in vitro of schistosomula- and adult worm-derived metabolic products on the proliferative response of splenic lymphocytes to soluble egg antigen (SEA) in mice infected with S. japonicum was studied. The results showed that the proliferative response of splenic lymphocytes to SEA in infected mice was enhanced when schistosomula-derived metabolic products were added to the in vitro culture of splenic lymphocytes and SEA (Fig. 1). However, adult worm-derived metabolic products had inhibitory effects on the proliferative response in the above mentioned culture (Fig. 2). It was suggested that there were certain regulative effects of schistosome-derived metabolic products on the proliferative response in mice infected with S. japonicum in vitro, and these regulative effects varied with the factors released by different developmental stages of schistosomes.