中国寄生虫学与寄生虫病杂志

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我国血吸虫病传染源快速检测技术的需求与发展

汪世平*,何鑫,周云飞   

  1. 中南大学基础医学院医学寄生虫学系,长沙 410078
  • 出版日期:2015-12-30 发布日期:2016-03-24

Demand for and the Development of Detection Techniques for Source of Schistosome Infection in China

WANG Shi-ping*, HE Xin, ZHOU Yun-fei   

  1. Department of Medical Parasitology, Xiangya School of Medicine, Central South University, Changsha 410078, China
  • Online:2015-12-30 Published:2016-03-24

摘要:

血吸虫病是一种严重危害人类健康的人畜共患寄生虫病,传染源的快速侦检是血吸虫病防治的关键。随着我国血吸虫病的有效控制,传染源检测技术也不断得到更新。目前,我国绝大部分血吸虫病流行区均已进入传播控制阶段,人畜感染率和感染强度明显下降,传统的病原学检测方法和常规免疫学技术难以满足现阶段对血吸虫病传染源快速检测的需求,血吸虫病基本消除阶段对检测方法的敏感性、特异性、稳定性,以及在快捷、简便和成本等方面提出了更高的要求。近年来,许多改良或新型检测技术开始应用到血吸虫病传染源的检测工作中,如自动显微图像扫描、PCR-ELISA、免疫传感检测技术和环介导同温扩增核酸检测技术等。新型血吸虫病传染源快速检测技术的研发,可为我国血吸虫病传染源快速检测技术的发展打开新的空间。

关键词: 血吸虫病, 传染源, 检测技术

Abstract:

Schistosomiasis is a type of zoonotic parasitosis that severely impairs human health. Rapid detection of infection sources is a key to the control of schistosomiasis. With the effective control of schistosomiasis in China, the detection techniques for infection sources have also been developed. The rate and the intensity of infection among humans and livestocks have been significantly decreased in China, as the control program has entered the transmission control stage in most of the endemic areas. Under this situation, the traditional etiological diagnosing techniques and common immunological methods can not afford rapid detection of infection sources of schistosomiasis. Instead, we are calling for detection methods with higher sensitivity, specificity and stability while being less time-consuming, more convenient and less costing. In recent years, many improved or novel detection methods have been applied for the epidemiological surveillance of schistosomiasis, such as the automatic scanning microscopic image acquisition system, PCR-ELISA, immunosensors, loop-mediated isothermal amplification, etc. The development of new monitoring techniques can facilitate rapid detection of schistosome infection sources in endemic areas.

Key words: Schistosomiasis, Infection source, Detection technique