奥氏棘球绦虫分子遗传标志特征及其流行病学研究进展

doi:10.12140/j.issn.1000-7423.2023.02.014

中国寄生虫学与寄生虫病杂志 ›› 2023, Vol. 41 ›› Issue (2): 213-218.doi: 10.12140/j.issn.1000-7423.2023.02.014

奥氏棘球绦虫分子遗传标志特征及其流行病学研究进展

孙慧¹(), 李立¹, 闫鸿斌¹, 李秀荣¹, 付宝权¹^,², 贾万忠¹^,²^,^*()

1 国家动物包虫病专业实验室，甘肃兰州 730046
2 江苏省动物重要疫病与人兽共患病防控协同创新中心，扬州 225009

收稿日期:2022-07-18 修回日期:2022-09-12 出版日期:2023-04-30 发布日期:2023-05-10
通讯作者: 贾万忠
作者简介:孙慧（1999-），女，硕士研究生，从事棘球蚴病免疫学和生物学研究。E-mail：2247300721@qq.com
基金资助:
国家重点研发计划(2021YFE0191600);家畜疫病病原生物学国家重点实验室项目(SKLVEB2020CGPY01)

Research progress on molecular markers and epidemiology of Echinococcus ortleppi

SUN Hui¹(), LI Li¹, YAN Hongbin¹, LI Xiurong¹, FU Baoquan¹^,², JIA Wanzhong¹^,²^,^*()

1 National Professional Laboratory for Animal Echinococcosis, Lanzhou 730046, Gansu, China
2 Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Disease, Yangzhou 225009, China

Received:2022-07-18 Revised:2022-09-12 Online:2023-04-30 Published:2023-05-10
Contact: JIA Wanzhong
Supported by:
National Key Research and Development Program of China(2021YFE0191600);Program of the State Key Laboratory of Veterinary Etiological Biology(SKLVEB2020CGPY01)

摘要/Abstract

摘要：

棘球蚴病是由棘球绦虫的中绦期幼虫引起的一种重要的人兽共患寄生虫病，在我国主要流行于西部地区。奥氏棘球绦虫的形态和发育特征与细粒棘球绦虫等存在显著差异，为棘球属内独立的种，其适宜中间宿主为牛。人、猪、骆驼、绵羊、山羊、狐猴和鹿等均可感染奥氏棘球蚴。本文对奥氏棘球绦虫形态学、遗传变异、分子遗传标记等特性和流行现状进行综述，为棘球蚴病的流行病学调查、防控和监测等提供参考依据。

关键词: 奥氏棘球绦虫, 分子遗传标志, 流行现状

Abstract:

Echinococcosis is an important zoonotic parasitic disease caused by the metacestode stage larval of the genus Echinococcus. In China, it is mainly endemic in the western region. E. ortleppi is a unique specie of Echinococcus, due to its morphological and developmental characteristics, which are significantly different from that of E. granulosus. Its suitable intermediate host is cattle. Humans, pigs, camels, sheep, goats, lemurs and deers can be infected with E. ortleppi. In this review, the morphology, genetic variation, molecular genetic markers and epidemiology of E. ortleppi were summarized to provide a reference for epidemiological investigation, prevention and control and monitoring of echinococcosis.

Key words: Echinococcus ortleppi, Molecular genetic makers, Epidemiology

中图分类号:

R383.33

孙慧, 李立, 闫鸿斌, 李秀荣, 付宝权, 贾万忠. 奥氏棘球绦虫分子遗传标志特征及其流行病学研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2023, 41(2): 213-218.

SUN Hui, LI Li, YAN Hongbin, LI Xiurong, FU Baoquan, JIA Wanzhong. Research progress on molecular markers and epidemiology of Echinococcus ortleppi[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2023, 41(2): 213-218.

图/表 2

表1

表2

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核基因	细粒棘球绦虫狭义种	奥氏棘球绦虫	序列差异率/％
elp	AB159143	FN582298	1.9
ef1a	AB306934	AB306937	1.3
pepck	FN567990	FN567992	1.5
pold	FN568361	FN568363	2.0
tgf	KY766917	KY766920	1.1
cal	KY766909	KY766912	1.1
Rpb2	FN566850	FN566852	1.2

国家	中间/终末宿主	感染数/人或只	参考文献
墨西哥	人	1	[30]
巴西	人、犬、牛	1、1、535	[7，32，59]
智利	牛	2	[33]
乌拉圭	牛		[34]
阿根廷	人、牛、犬	1、51、2	[35]
玻利维亚	牛、犬	5、2	[36]
意大利	牛	1	[37]
荷兰	人	1	[41]
法国	人、牛	4、7	[38，61]
波兰	灰狼、人	1、1	[31，40]
英国	斑鹿	1	[12]
波斯尼亚和黑塞哥维那	豪猪	1	[62]
德国	人	1	[63]
瑞士	人	1	[63]
印度	牛、水牛、猪、人	3、2、4、1	[8，42]
尼泊尔	水牛、绵羊、山羊	14、2、2	[10]
不丹	牛	1	[43]
越南	猴、人	1、2	[8，44]
中国	人	1	[45]
巴基斯坦	牛	8	[46]
伊朗	骆驼、绵羊、山羊	1、1、1	[9，47]
土耳其	犬	1	[48]
埃及	骆驼	1	[49]
苏丹	骆驼	1	[50]
埃塞俄比亚	牛、猪	12、1	[51，53]
肯尼亚	牛、猪、山羊、骆驼、绵羊、犬	71、1、3、 2、1、1	[45，51，53，59]
纳米比亚	牛、羚羊、斑马	35、3、1	[53，59]
赞比亚	牛、猪	52、1	[63]

奥氏棘球绦虫分子遗传标志特征及其流行病学研究进展

Research progress on molecular markers and epidemiology of Echinococcus ortleppi

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