绦虫排泄分泌物与宿主免疫效应的相关研究进展

doi:10.12140/j.issn.1000-7423.2020.01.020

摘要/Abstract

摘要： 绦虫是常见的人兽共感染寄生虫。绦虫排泄分泌物（ESP）是绦虫在感染过程中分泌/排泄并直接暴露于宿主免疫系统的产物,是最可能引起宿主免疫效应变化的原因之一。近年来大量研究显示,该物质可诱导和调控宿主的免疫应答,与绦虫感染密切相关。绦虫ESP可诱导宿主产生正向免疫效应来控制感染,亦可诱导宿主产生负向免疫效应,从而逃避宿主的免疫攻击,建立长期感染。本文对绦虫ESP与宿主免疫效应的相关研究作一简要综述。

关键词: 绦虫, 排泄分泌物, 免疫效应

Abstract: Cestodes are common zoonotic parasites. The excretory/secretory products (ESPs) of cestodes are produced during the infection and exposed directly to the host immune system, being one of the most possible effectors causing the changes of host immune responses. In recent years, a wealth of studies have shown that ESPs can induce and regulate the host immune responses, which are closely related to the cestodes infection. Cestodes ESPs can induce host’s positive immune response to control the infection, and also induce negative immune response, enabling the cestodes to evade the host immune attacks. thus resulting in establishment of a long-time infection. This paper presents a brief review on the relations between cestode ESPs and host immune response.

Key words: Cestode, Excretory/secretory product, Immunological effect

中图分类号:

R383.3

范贤敏, 周必英. 绦虫排泄分泌物与宿主免疫效应的相关研究进展[J]. 中国寄生虫学与寄生虫病杂志, 2020, 38(1): 128-133.

FAN Xian-min, ZHOU Bi-ying. Research advances on the relationship between cestode excretory/secretory products and host immune response[J]. Chinese Journal of Parasitology and Parasitic Diseases, 2020, 38(1): 128-133.

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