关键词: 肝泡状棘球蚴病, 门静脉, 阿苯达唑, 碘油, 病理学

Abstract: 【Abstract】 Objective  To observe the morphological change in the pathological process of Echinococcus multilocularis in liver of infected rats after treatment with liposome entrapped albendazole and iodized oil suspension through portal vein, and investigate its efficacy against hepatic alveolar echinococcosis.   Methods  One Echinococcus multilocularis- infected rat served as control. Another 19 infected rats were infused with 0.2 ml liposome entrapped albendazole and iodized oil suspension through portal vein. At 4, 7 and 10 d after treatment, the rats were sacrificed for further observation. The E. multilocularis metacestodes were collected, and the pathological change of alveolar hydatid was observed with hematoxylin-eosin staining and toluidine blue staining.  Results  In four days post treatment, E. multilocularis metacestodes were normal. On the 7th day and 10th day post treatment, the major pathological change was degeneration and necrosis, respectively. A great quantity of liposomes and iodized oil deposited in the metacestodes, and caused breakdown of E. multilocularis tissue, collapse of cysts, cataplasia of germinal layer and laminated layer.  Conclusion  Interventional therapy trans-hepatic vein may be an effective way to treat hepatic alveolar echinococcosis.

Key words: Hepatic alveolar echinococcosis, Portal vein, Albendazole, Iodized oil, Pathology