中国寄生虫学与寄生虫病杂志 ›› 2010, Vol. 28 ›› Issue (1): 13-57.

• 现场研究 • 上一篇    下一篇

云南省8个边境州市19个口岸入境者疟疾血清学检测

陈国伟1, 王军2, 黄兴周2, 李亚萍2, 侯中生2, 李华宪1, 许时燕1, 魏春1, 张再兴1   

  1. 1 云南省寄生虫病防治所、云南省疟疾研究中心,思茅 665000;2 云南省出入境检验检疫局,昆明 650228
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2010-02-28 发布日期:2010-02-28

Serological Detection of Malaria for People Entering China from19 Ports of Entry Covering 8 Border Prefectures of Yunnan

CHEN Guo-wei1,WANG Jun2,HUANG Xing-zhou2,LI Ya-ping2,HOU Zhong-sheng2,LI Hua-xian1,XU Shi-yan1,WEI Chun1,ZHANG Zai-xing1   

  1. 1 Yunnan Institute of Parasitic Disease,Yunnan Center for Malaria Control,Simao 665000,China;2 Yunnan Provincial Bureau of Inspection and Quarantine for Exit and Entry Frontier,Kunming 650000,China
  • Received:1900-01-01 Revised:1900-01-01 Online:2010-02-28 Published:2010-02-28

摘要: 目的 了解云南省8个边境州(市)19个口岸入境者疟疾流行情况,评价境外输入性疟疾对云南省边境地区疟疾流行态势的影响。 方法 2007年3~12月对云南省中-越、中-老和中-缅边境19个口岸的入境者进行问卷调查,同时采血,制滤纸干血滴,6月30日前为上半年血样、7月1日后为下半年血样进行间接荧光抗体试验(IFAT)检测,计算疟疾抗体阳性率和阳性几何平均滴度倒数(GMRT),结合疾病监测信息报告管理系统的疟疾疫情资料,分析输入性疟疾与云南省边境地区疟疾流行态势之间的关系。 结果 下半年入境者的IFAT阳性率(5.6%)比上半年(4.4%)高20.9%(χ2=12.95,P<0.05)。上半年入境者的GMRT(47.90)高于下半年(42.89)。8个边境州(市)入境者IFAT阳性率与境内当年的疟疾病例数之间呈正相关(r=0.812 4,P<0.05),IFAT阳性率位居前3位的是德宏州(8.6%)、保山市(7.1%)和临沧市(6.5%)。中-缅边境口岸入境者的IFAT阳性率最高(6.8%),前5位的为吕良(15.2%)、拉影(12.2%)、姐告(11.1%)、猴桥(10.1%)和清水河(8.0%);中国籍入境者的IFAT阳性率随境外停留天数的增加而上升,户籍遍及31个省(市、自治区)。缅甸籍入境者IFAT阳性率最高(11.7%),其次为我国云南籍入境者(3.7%)。 结论 IFAT是一种可行的疟疾检测方法,境外疟疾流行态势在一定程度上影响我国云南边境地区的疟疾流行。

关键词: 疟疾, 入境人员, 间接荧光抗体试验, 云南, 缅甸

Abstract: Objective To evaluate malaria situation in areas of Yunnan Province bordering with Myanmar, Laos and Vietnam. Methods Blood samples on filter paper were collected from the entry people in March to December of 2007 involving 19 national and provincial ports of entry. Indirect fluorescent antibody test (IFAT) was carried out by using the blood samples collected before June 30 as the first half year and after July 1 as the second half year. Analysis was made on the relationship of IFAT positive rate and GMRT to malaria incidence in the province reported by the China information system for disease control and prevention. Results IFAT positive rate in the first half year (5.6%) was 20.9% higher than that of second half year (4.4%) (χ2=12.95%, P<0.05). There was a positive correlation between IFAT positive rate and the number of malaria cases reported in 2007 from the 8 bordering prefectures (r=0.812 4, P<0.05). The highest IFAT positive rate was found in Dehong (8.7%), Baoshan (7.1%), and Lingcang (6.5%). Among the 19 entry ports, the highest IFAT positive rate was found in 5 entry ports: Lvliang, Laying, Jiegao, Houqiao, and Qingshuihe, all in China-Myanmar border. The IFAT positive rate in the Chinese entry people increased with their days of staying outside the border. Among the entry people, the highest antibody positive rate was from those of Myanmar nationality (11.7%) followed by those from Yunnan (3.7%). Conclusion To certain extent, higher malaria incidence outside the border impacts that of Yunnan Province.

Key words: Malaria, Entry people, Indirect fluorescent antibody test, Yunnan, Myanmar