复方蒿甲醚片治疗间日疟的效果

中国寄生虫学与寄生虫病杂志 ›› 1999, Vol. 17 ›› Issue (3): 15-177.

复方蒿甲醚片治疗间日疟的效果

李兴亮¹,李崇珍¹,车立刚¹,刘行知¹,李宗惠¹,黄德顺²,何伟³,刀清勇³

1　云南省疟疾防治研究所　思茅　6650002　勐腊农场卫生科　勐腊　6663003　勐腊农场六分场卫生所　勐腊　666300

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1999-06-30 发布日期:1999-06-30

OBSERVATION ON EFFICACY OF ARTEMETHER COMPOUND AGAINST VIVAX MALARIA

LI Xingliang ¹;LI Chongzhen ¹;CHE Ligang ¹;LIU Xingzhi ¹ LI Zonghui ¹;HUANG Deshun²;HE Wei³;DAO Qingyang ³

1 lnstitute of Malaria Prevention and Treatment of Yunnan Province;Simao 665000 2 Health Section of Meng la Farm ,Meng la 6663003　The Sixth Branch Hospital of Meng la Farm ,Meng la 666300

Received:1900-01-01 Revised:1900-01-01 Online:1999-06-30 Published:1999-06-30

摘要/Abstract

摘要： 　　目的：观察复方蒿甲醚片治疗间日疟疗效的影响。方法：用复方蒿甲醚片（每片含苯芴醇１２０ｍｇ、蒿甲醚２０ｍｇ）１６片３ｄ分服（Ａ组）、２０片５ｄ分服（Ｂ组），氯喹伯氨喹８日疗法（Ｃ对照组）三组分别治疗３６例、４１例和５５例。结果：Ａ、Ｂ、Ｃ三组的平均退热时间相近，分别为２２．３ｈ、２３．２ｈ和２５．０ｈ；平均原虫转阴时间为３３．５ｈ、３０．５ｈ和４４．９ｈ；Ａ、Ｂ两组均显著快于Ｃ组（Ｐ＜０．０１）。治后９个月的临床复发率：Ａ、Ｂ、Ｃ组各为８４．９％、７８．８％和２２．９％；Ａ、Ｂ组均显著高于Ｃ组（Ｐ均＜０／０１）。结论：两种治疗方案治疗间日疟均具有速效。

关键词: 复方蒿甲醚, 间日疟, 临床疗效, 复发

Abstract:

　AIM: To observe the efficacy of artemether compound against vivax malaria. METHODS: Each artemether compound tablet contains 120 mg benflumetolum and 20 mg artemether.132 patients with vivax malaria were divided into 3 groups.Group A,36 patients received 8 tablets as an initial dose,followed by 4 tablets daily for 2 days;group B,41 patients received 8 tablets as an initial dose, followed by 3 tablets daily for 4 days;group C,55 patients receiving chloroguine primaquine served as control.Two patients of group A were voluntarily to be bitten by Anopheles dirus before and after medication to observe the influence of artemether compound on the sporogony. RESULTS: The average defervescence times for groups A,B and C were 22.3 h、23.2 h and 25.0 h( P >0.05),respectively,the average parasite clearance times were 33.5 h、30.5 h and 44.9 h,respectively,the average parasite clearance times of groups A and B were all significantly shorter than that of group C ( P <0.01).The replase rates of groups A,B and C were 84.9%、78.8% and 22.9%, respectively,followed up at nine months,the relapse rates of groups A and B were higer than that of group C( P <0.01). CONCLUSION: Two regimens of artemether compound have the advantage of high efficacy against vivax malaria.

Key words: Artemether compound, vivax malaria, efficacy, relapse

李兴亮;李崇珍;车立刚;刘行知;李宗惠;黄德顺;何伟;刀清勇. 复方蒿甲醚片治疗间日疟的效果[J]. 中国寄生虫学与寄生虫病杂志, 1999, 17(3): 15-177.

LIXingliang;LIChongzhen;CHELigang;LIUXingzhiLIZonghui;HUANGDeshun;HEWei;DAOQingyang. OBSERVATION ON EFFICACY OF ARTEMETHER COMPOUND AGAINST VIVAX MALARIA[J]. Chinese Journal of Parasitology and Parasitic Diseases, 1999, 17(3): 15-177.

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