中国寄生虫学与寄生虫病杂志 ›› 1998, Vol. 16 ›› Issue (2): 1-83.

• 论著 •    下一篇

云南南部恶性疟原虫对咯萘啶敏感性的纵向监测

杨恒林;刘德全;黄开国;张春勇;李春富;   

  1. 1 云南省疟疾防治研究所; 2 中国预防医学科学院寄生虫病研究所;
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:1998-04-30 发布日期:1998-04-30

LONGITUDINAL SURVEILLANCE OF SENSITIVITY OF PLASMODIUM FALCIPARUM TO PYRONARIDINE IN SOUTH YUNNAN

Yang Henglin 1;Liu Dequan 2;Huang Kaiguo 1;Zhang Chunyong 2;Li Chunfu 1   

  1. 1 Institute of Malaria Prevention and Treatment of Yunnan Province,Simao 665000 2 Institute of Parasitic diseases; Chinese Academy of Preventive Medicine, Shangh 200025;
  • Received:1900-01-01 Revised:1900-01-01 Online:1998-04-30 Published:1998-04-30

摘要: 目的:了解恶性疟原虫对咯萘啶敏感性的变化,以指导合理用药。方法:采用WHO体内四周法及体外微量测定法,在云南南部勐腊县进行敏感性纵向监测。结果:1984-1985年和1995年体内观察分别为36例和39例,其平均退热时间分别为32.7h±16.0h和56.2h±27.4h。无性体转阴时间分别为64.2h±22.9h及55.3h±11.8h。复燃率分别为15.2%(5/33)和37.5%(9/24)。1988、1990、1992和1995年体外测得ID50分别为13.0nmol/L、20.0nmol/L、32.0nmol/L和40.0nmol/L。ID95依次为48.0nmol/L、136.0nmol/L、325.0nmol/L和330.0nmol/L。抗性率分别为0、8.8%、13.8%及36.4%。结论:当地恶性疟原虫对咯萘啶的敏感性呈下降趋势。

关键词: 疟疾, 恶性疟原虫, 体内, 体外测定, 敏感性, 咯萘啶

Abstract:

AIM: To understand the changes in the sensitivity of Plasmodium falciparum to pyronaridine in the south of Yunnan Province. METHODS: WHO standard in vivo and in vitro microtest was used. RESULTS: In 1984-1985 and 1995, 36 and 39 cases of acute falciparum malaria were observed, the average defervescence time being 32 7±16 0 h and 56 2±27 4 h, the mean asexual parsite clearance time, 64 2±22 9 h and 55 3±11 8 h, and the recrudescence rate of patients followed up for 28 days, 15 2%(5/33) ...

Key words: Malaria, P.falciparum, in vivo, in vitro, assay, sensitivity, pyronaridine