关键词: 靶向伯氨喹, 约氏疟原虫, 红外期, 大鼠, 小鼠

Abstract: Target primaquine(TPQ) the primaquine entrapped by galactosylneoglycoalbumin(G NGA),was given intravenously(iv)to Wistar rats 2 h after sporozoite inoculation.The sporozoite viability(SPV) of TPQ 20 mg/kg group was revealed to be 1.2% 42 h after inoculation,which showed a decline of about 6% as compared to the control;besides,degeneration or retardation of development was present in 90% of EEF.In TPQ 10 mg/kg and PQ 20 mg/kg groups,the SPV were 2.8% and 5.0%, respectively,showing drops by 15% and 26% as compared with that of the control.Degeneration or retardation in development was also visible in about half of the EEF.In mice which were treated iv with TPQ 10 mg/kg or PQ 20 mg/kg 2 h after sporozoite inoculation,the prepatent periods were delayed markedly as compared with that of the control.Parasitemia did not appear in 2 mice in 10 mg/kg TPQ group further indicated the effectiveness of the drug.The results suggest that the anti EEF effect of TPQ is apparently more promising than that of PQ.