中国寄生虫学与寄生虫病杂志 ›› 1990, Vol. 8 ›› Issue (2): 96-99.

• • 上一篇    下一篇

阿苯达唑、噻嘧啶治疗肠道线虫及控制钩虫感染回升的效果

张孝蓉,杨文锦,杨超,廖祖瑜,刘映铭,唐中玖,冯大光,陶斯象,郭兴前,何守全,罗明正   

  1. 四川省医学科学院寄生虫病防治研究所; 四川省医学科学院寄生虫病防治研究所; 四川省医学科学院寄生虫病防治研究所; 四川省医学科学院寄生虫病防治研究所; 四川省医学科学院寄生虫病防治研究所; 四川省医学科学院寄生虫病防治研究所; 南充地区卫生防疫站; 南充地区卫生防疫站; 武胜县卫生防疫站; 武胜县卫生防疫站; 武胜县卫生防疫站
  • 收稿日期:2017-01-09 修回日期:2017-01-09 出版日期:1990-05-31 发布日期:2017-01-09

EFFECT OF ALBENDAZOLE AND PYRANTEL IN TREATING INTESTINAL HELMINTHIASIS AND CONTROLLING THE RECURRENCE OF HOOKWORM INFECTIONS

  • Received:2017-01-09 Revised:2017-01-09 Online:1990-05-31 Published:2017-01-09

摘要: 采用阿苯达唑400mg/d×3d、400mg/d×5d和噻嘧啶1500mg/d×3d、1500mg/d×5d治疗肠道线虫感染者720例。治后半月检查,钩虫卵阴转率分别为98.6、98.6、86.2和93.5%;蛔虫卵阴转率分别为96.5、98.2、92.9和96.3%;鞭虫卵阴转率分别为86.4、89.0、68.9和67.0%。钩虫卵减少率均在98.0%以上。治后半年复查,各组钩虫阳性率均有不同程度回升,虫种由治前美洲钩虫为主,转为十二指肠钩虫为主。结果显示,回升的原因主要是十二指肠钩虫引起,而阿苯达唑400mg/d×3d和400ms/d×5d控制钩虫感染回升有明显作用。

关键词: 阿苯达唑, 噻嘧啶, 十二指肠钩虫移行幼虫, 肠道线虫

Abstract: A total of 720 human intestinal helminthic infections were divided into 4 groups and treated with albendazole 400mg/d × 3d, 400mg/d × 5d, pyrantel 1 500mg/d × 3d, or 1 500mg/d×5d. Half a month after treatment, the negative rates of hookworm egg were 98.6, 98.6, 86.2 and 93.5%, those of ascaris egg were 96.5, 98.2, 92.9 and 96.3%, and those of whipworm egg were 86.4, 89.0, 68.9 and 67.0% respectively. Reduction rate of hookworm egg reached more than 98% in all the 4 groups. Six months after treatment, however, the positive rates of all the 4 groups rose again in varying degrees. The predominant species of hookworm infections was Necator americanus before the treatment and Ancylostoma duodenale after the treatment. It was demonstrated that the recurrence of hookworm infection resulted from A. duodenale infections, while a single dose of 400mg albendazole per day for 3 or 5 days showed good effect in controlling the recurrence of, hookworm infections in a certain area.