关键词: 棘隙吸虫病, 吡喹酮治疗, 日本, 药物副作用, 治疗观察, 分层随机抽样, 治疗药物, 实际应用, 阴转率, 统计学处理

Abstract: Pyquiton was given in a single dose of 20, 10 and 5mg/kg to 15, 17 and 17 patients with Echinochasmus japonicus infection respectively. 7-10 days after treatment the cure rates of the treated groups were 93.3%, 94.1% and 100% respectively. After 1 month, the cure rates were 86.7%, 94.1% and 100%. In addition, one patient who was given a single dose of 2mg/kg was found egg negative 7-10 days after treatment but became egg positive after one month. The drug was well tolerated. The preliminary results showed that pyquiton was highly effective with mild side effects in the treatment of Echinochasmus japonicus infection.